Publications by authors named "Shefali R Bijwadia"
Article Synopsis
- Prolonged bedrest and lack of physical activity after traumatic musculoskeletal injuries, particularly volumetric muscle loss (VML), can severely limit muscle adaptability and cause metabolic issues.
- In a study with adult mice, activity restriction combined with VML increased carbohydrate usage and altered metabolic ratios, indicating lower capacity for fatty acid oxidation, while the overall muscle metabolome remained unchanged.
- The findings suggest that VML injury leads to changes in fatty acid metabolism, which could be worsened by reduced activity, potentially leading to triglyceride accumulation in muscle.
Volumetric muscle loss (VML) is associated with persistent functional impairment due to a lack of de novo muscle regeneration. As mechanisms driving the lack of regeneration continue to be established, adjunctive pharmaceuticals to address the pathophysiology of the remaining muscle may offer partial remediation. Studies were designed to evaluate the tolerance and efficacy of two FDA-approved pharmaceutical modalities to address the pathophysiology of the remaining muscle tissue after VML injury: (1) nintedanib (an anti-fibrotic) and (2) combined formoterol and leucine (myogenic promoters).
View Article and Find Full Text PDFMitochondria are central players in host immunometabolism as they function not only as metabolic hubs but also as signaling platforms regulating innate immunity. Environmental exposures to mitochondrial toxicants occur widely and are increasingly frequent. Exposures to these mitotoxicants may pose a serious threat to organismal health and the onset of diseases by disrupting immunometabolic pathways.
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- Dopamine neuron loss plays a key role in the pathology of Parkinson's Disease (PD), a neurodegenerative disorder affecting millions, highlighting the need for research on its genetic and environmental factors for better prevention and treatment.
- Established models using the transparent nematode C. elegans allow easy visualization of neuronal changes, particularly in dopamine neurons, through fluorescent reporters that track morphological shifts.
- A new seven-point universal scoring system for assessing dendritic degeneration in C. elegans offers a detailed method for analyzing neuron health, enabling researchers to capture subtle and significant morphological changes that were previously overlooked.