Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence.

Uroplakin (UP) tetraspanins and their associated proteins are major mammalian urothelial differentiation products that form unique two-dimensional crystals of 16-nm particles ("urothelial plaques") covering the apical urothelial surface. Although uroplakins are highly expressed only in mammalian urothelium and are often referred to as being urothelium specific, they are also expressed in several mouse nonurothelial cell types in stomach, kidney, prostate, epididymis, testis/sperms, and ovary/oocytes. In oocytes, uroplakins colocalize with CD9 on cell-surface and multivesicular body-derived exosomes, and the cytoplasmic tail of UPIIIa undergoes a conserved fertilization-dependent, Fyn-mediated tyrosine phosphorylation that also occurs in eggs.

Fate of cryopreserved donor embryos.

Objective: To review a center's experience with cryopreserved embryos generated from donor eggs and to analyze their long-term disposition.

Design: Retrospective analysis of donor egg cycles with cryopreserved embryos.

Setting: University-based IVF program.

Comparison of pregnancy outcomes in anonymous shared versus exclusive donor oocyte in vitro fertilization cycles.

Objective: To determine whether there is a difference in pregnancy outcomes between women undergoing a shared versus exclusive donor oocyte cycle.

Design: Retrospective analysis.

Setting: University IVF center.

Comparison of pregnancy outcomes in elective single blastocyst transfer versus double blastocyst transfer stratified by age.

Objective: To determine whether there is a difference in pregnancy outcomes, stratified by age, between women undergoing elective single blastocyst transfer (eSBT) versus those undergoing double blastocyst transfer (2BT).

Design: Retrospective analysis.

Setting: University IVF center.

Women with cancer undergoing ART for fertility preservation: a cohort study of their response to exogenous gonadotropins.

Cancer patients produce similar numbers of oocytes after ovarian hyperstimulation compared with age-matched infertile controls, suggesting that malignancy does not adversely affect ovarian response.

Heterotopic abdominal pregnancy following two-blastocyst embryo transfer.

Objective: To report a case of a heterotopic primary abdominal pregnancy after two-blastocyst IVF-ET.

Design: Case report.

Setting: University-based IVF program.