Publications by authors named "Sheetal S Rao"
We hypothesized that combining adoptively transferred autologous T cells with a cancer vaccine strategy would enhance therapeutic efficacy by adding antimyeloma idiotype (Id)-keyhole limpet hemocyanin (KLH) vaccine to vaccine-specific costimulated T cells. In this randomized phase 2 trial, patients received either control (KLH only) or Id-KLH vaccine, autologous transplantation, vaccine-specific costimulated T cells expanded ex vivo, and 2 booster doses of assigned vaccine. In 36 patients (KLH, n = 20; Id-KLH, n = 16), no dose-limiting toxicity was seen.
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- Immune evasion is a key aspect of cancer progression, and understanding myeloid-derived suppressor cells (MDSCs) is crucial, but current research is limited due to the lack of specific markers.
- Researchers developed a new method using competitive peptide phage display to create peptide-Fc fusion proteins, called peptibodies, that specifically target MDSCs.
- In studies with tumor-bearing mice, injecting these peptibodies effectively depleted both types of MDSCs without harming other immune cells and showed greater tumor growth inhibition compared to traditional methods, suggesting potential for new cancer diagnostics and treatments.