Publications by authors named "Sheena MacLeod"
Article Synopsis
- * Testing the functionality of these targeted viruses involves assessing reporter gene expression and performing competition assays with ligands to confirm effective binding.
- * Additionally, using fluorescent labeling and antibody techniques helps visualize how the virus interacts with its receptors, which is crucial for validating the targeting process before larger tests.
Adenoviruses with deletions of viral genes have been extensively studied as potential cancer therapeutics. Although a high degree of cancer selectivity has been demonstrated with these conditionally replicating adenoviruses, low levels of virus replication can be detected in normal cells. Furthermore, these mutations were also found to reduce the activity of the replicating viruses in certain cancer cells.
View Article and Find Full Text PDFObjectives: The purpose of this review was to determine the nature of support that mental health nurses could deliver to carers of people diagnosed with schizophrenia. The aim was to identify approaches that could be delivered within community practice to reduce burden and increase knowledge, mental health and coping. QUESTIONS ADDRESSED: What effect did support have on carer burden and other needs? What were the key elements of effective support? What effective supports could mental health nurses deliver within practice?
Design: This review covers the international scientific literature published between 1980 and 2008.