Comparative Analysis of Thromboxane B2 (TXB2) and Prostaglandin E2 (PGE2) Levels in the Gingival Crevicular Fluid (GCF) of Diabetic Patients With Chronic Periodontitis: An Enzyme Immunoassay Study.

Introduction: A persistent systemic hyperglycemia as observed in patients with type 2 diabetes mellitus (DM) has been associated with periodontal inflammation. Therefore, the primary objective of the present study was to assess the levels of thromboxane B2 (TXB2) and prostaglandin E2 (PGE2) in the gingival crevicular fluid (GCF) of type 2 DM and non-diabetic patients with chronic periodontitis. The secondary objectives were to correlate these levels with various parameters such as age, gender, glycated hemoglobin (HbA1c) levels, probing depth (PD), and fasting blood sugar levels and to determine the significant predictors for PGE2 and TXB2 levels.

Comparative Analysis of Turmeric and Chlorhexidine Mouthwashes as Anti-plaque and Anti-gingivitis Agents: An Observational Study.

Introduction: Mouthwashes are highly efficacious chemical agents for managing plaque and gingivitis. The aim of the present study was to evaluate and compare the efficacy of turmeric (TM) and chlorhexidine (CHX) mouthwash as anti-plaque and anti-gingivitis agents.

Materials And Methods: This retrospective, observational study was conducted on the clinical case records of 60 patients with gingival and plaque scores of ≥ 1, who were treated with TM mouthwash as group 1 and CHX mouthwash as group 2 for a period of two months.

Immunomodulatory Effect of Phytoactive Compounds on Human Health: A Narrative Review Integrated with Bioinformatics Approach.

Background: Immunomodulation is the modification of immune responses to control disease progression. While the synthetic immunomodulators have proven efficacy, they are coupled with toxicity and other adverse effects, and hence, the efforts were to identify natural phytochemicals with immunomodulatory potential.

Objective: To understand the immunomodulatory properties of various phytochemicals and investigate them in species extracts using an approach.

Liver Disease and Cell Therapy: Advances Made and Remaining Challenges.

The limited availability of organs for liver transplantation, the ultimate curative treatment for end stage liver disease, has resulted in a growing and unmet need for alternative therapies. Mesenchymal stromal cells (MSCs) with their broad ranging anti-inflammatory and immunomodulatory properties have therefore emerged as a promising therapeutic agent in treating inflammatory liver disease. Significant strides have been made in exploring their biological activity.

TGFβ priming enhances CXCR3-mediated mesenchymal stromal cell engraftment to the liver and enhances anti-inflammatory efficacy.

The immunomodulatory characteristics of mesenchymal stromal cells (MSC) confers them with potential therapeutic value in the treatment of inflammatory/immune-mediated conditions. Previous studies have reported only modest beneficial effects in murine models of liver injury. In our study we explored the role of MSC priming to enhance their effectiveness.

Two Zn(II)/Cd(II) Coordination Polymers as Recyclable Heterogeneous Catalysts for an Efficient Room-Temperature Synthesis of α-Aminonitriles via the Solvent-Free Strecker Reaction.

The α-aminonitriles are versatile building blocks in the synthesis of natural or artificial amino acids as well as important intermediates in organic synthesis. For their synthesis, the three-component Strecker reaction involving an aldehyde or a ketone together with amines and trimethylsilyl cyanide is used. In the literature, hydrothermally produced metal-based heterogeneous Lewis acid catalysts have been utilized in various solvents.

Luminescent 2D Pillared-Bilayer Metal-Organic Coordination Networks for Selective Sensing of ReO in Water.

For the preference in nuclear energy, one of the high-level liquid waste materials in the form of pertechnetate anion (TcO) has become an environmental hazard due to its mobility into groundwater and soil. For its sequestration, numerous efforts have been reported in recent years. However, its selective sensing, even using its nonradioactive surrogate oxidizing perrhenate ion (ReO), in aqueous media is very limited.

Cell Therapy for Liver Disease: From Promise to Reality.

Over the last decade, there has been a considerable progress in the development of cell therapy products for the treatment of liver diseases. The quest to generate well-defined homogenous cell populations with defined mechanism(s) of action has enabled the progression from use of autologous bone marrow stem cells comprising of heterogeneous cell populations to allogeneic cell types such as monocyte-derived macrophages, regulatory T cells, mesenchymal stromal cells, macrophages, etc. There is growing evidence regarding the multiple molecular mechanisms pivotal to various therapeutic effects and hence, careful selection of cell therapy product for the desired putative effects is crucial.

Cellular therapies for the treatment of immune-mediated GI and liver disease.

Introduction: Immune-mediated liver and gastrointestinal diseases are chronic conditions that lack curative treatments. Despite advances in the understanding and treatment of these conditions, they frequently remain refractory to treatment and represent a significant unmet need. Cellular therapies are an emerging option and hold the potential to have a major impact.

Design and Construction of a Luminescent and Highly Stable 3D Metal-Organic Framework with a [Zn(μ-OH)] Core.

A highly stable and luminescent 3D metal-organic framework (MOF), {[Zn(μ-OH)(BTC)(BBI4PY)]·10HO} (), with a rare [Zn(μ-OH)] core has been synthesized using a new rigid and functionalized pillar linker, 2,6-bis(pyridin-4-yl)-1,7-dihydrobenzo[1,2-:4,5-']diimidazole (BBI4PY) in combination with Zn(OAc)·2HO and 1,3,5-benzenetricarboxylic acid (HBTC) under solvothermal conditions. Unlike other MOFs with the [Zn(μ-OH)] core, was synthesized without using an external base, as the intrinsic basicity of BBI4PY served the purpose. Furthermore, it retains crystallinity and phase purity up to 350 °C on the basis of TGA and in situ variable temperature PXRD, correlating with its solid-state structure.

Comparative effect of indomethacin (IndoM) on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in the kidney, small intestine and liver of rats.

Indomethacin (IndoM) has prominent anti-inflammatory and analgesic-antipyretic properties. However, high incidence and severity of side-effects on the structure and functions of the kidney, liver and intestine limits its clinical use. The present study tested the hypothesis that IndoM causes multi-organ toxicity by inducing oxidative stress that alters the structure of various cellular membranes, metabolism and hence functions.

Time to endoscopy for acute upper gastrointestinal bleeding: Results from a prospective multicentre trainee-led audit.

Background: Endoscopy within 24 h of admission (early endoscopy) is a quality standard in acute upper gastrointestinal bleeding (AUGIB). We aimed to audit time to endoscopy outcomes and identify factors affecting delayed endoscopy (>24 h of admission).

Methods: This prospective multicentre audit enrolled patients admitted with AUGIB who underwent inpatient endoscopy between November and December 2017.

Provider reported barriers and solutions to improve testing among tuberculosis patients 'eligible for drug susceptibility test': A qualitative study from programmatic setting in India.

Background: In a study conducted in Bhopal district (a setting with facility for molecular drug susceptibility testing (DST)) located in central India in 2014-15, we found high levels of pre-diagnosis attrition among patients with presumptive multi drug-resistant tuberculosis (MDR-TB)-meaning TB patients who were eligible for DST, were not being tested.

Objectives: In this study, we explored the health care provider perspectives into barriers and suggested solutions for improving DST.

Methods: This was a descriptive qualitative study.

Retrospective Study of Root Canal Configurations of Mandibular Third Molars Using CBCT- Part-II.

Introduction: Abnormal root canal morphologies of third molars can be diagnostically and technically challenging during root canal treatment.

Aim: The aim of this retrospective study was to investigate the root and canal morphology of mandibular third molars in Central India population by using Cone Beam Computed Tomography (CBCT) analysis.

Materials And Methods: CBCT images of 171 mandibular third molars were observed and data regarding number of roots, number of canals, Vertucci's classification in each root, prevalence of C shaped canal, gender and topographical relation of morphology in mandibular third molar was statistically evaluated.

High pre-diagnosis attrition among patients with presumptive MDR-TB: an operational research from Bhopal district, India.

Background: Pre-diagnosis attrition needs to be addressed urgently if we are to make progress in improving MDR-TB case detection and achieve universal access to MDR-TB care. We report the pre-diagnosis attrition, along with factors associated, and turnaround times related to the diagnostic pathway among patient with presumptive MDR-TB in Bhopal district, central India (2014).

Methods: Study was conducted under the Revised National Tuberculosis Control Programme setting.

Understanding the sensory irregularities of esophageal disease.

Symptoms relating to esophageal sensory abnormalities can be encountered in the clinical environment. Such sensory abnormalities may be present in demonstrable disease, such as erosive esophagitis, and in the ostensibly normal esophagus, such as non-erosive reflux disease or functional chest pain. In this review, the authors discuss esophageal sensation and the esophageal pain system.

Management of Class-II Furcation Complicated with Endodontic involvement using Two Different Regenerative Materials.

This paper presents a case series of furcation involved teeth complicated with endodontic involvement which were treated with periodontal, endodontic and restorative procedures using different bone regenerative materials like; (a) Calcium phosphosilicate bone substitute having bioactive glass 69% mixed with glycerin 19% and poly-ethylene 12% dispensed in a putty form; (b) hydroxyapatite 70% and β-tricalcium phosphate 30% dispensed in granular form. All the cases were randomly selected having Grade II furcation defect with primary or secondary endodontic involvement. All cases were under observation for a period of 9 months.

Evaluation of Fracture Resistance of Endodontically Treated Teeth Filled with Gutta-Percha and Resilon Obturating Material: An In Vitro Study.

Background: As per many studies endodontically treated teeth are widely considered to be more susceptible to fracture than vital teeth. Obturation strains and post placement have been a major cause of vertical root fracture. Present study was conducted to compare in vitro fracture resistance after filling with either Gutta-percha or Resilon by lateral condensation techniques in root canals.

Effect of saliva contamination on the shear bond strength of a new self-etch adhesive system to dentin.

Aims And Objectives: To evaluate the effect of saliva contamination on the shear bond strength of a new two-step self-etch adhesive (P90 system adhesive) to dentin and to determine the effect of contaminant removing treatments on the recovery of bond strengths.

Materials And Methods: The buccal surfaces of 40 human premolars were ground to expose dentin. The specimens were randomly divided into four groups.

Severe asymptomatic non-alcoholic fatty liver disease in routine diabetes care; a multi-disciplinary team approach to diagnosis and management.

Objectives: To prospectively use a non-invasive algorithm to identify asymptomatic, advanced non-alcoholic fatty liver disease (NAFLD) in a secondary care diabetes clinic and to determine the short-term effect of a multi-disciplinary team (MDT) approach in a liver clinic.

Research Design And Methods: NAFLD Fibrosis Score (NFS) was calculated in 64 asymptomatic patients with type 2 diabetes. Advanced fibrosis was identified using transient elastography and confirmed with liver biopsy.

Studies on the protective effect of dietary fish oil on uranyl-nitrate-induced nephrotoxicity and oxidative damage in rat kidney.

Human and animal exposure demonstrates that uranium is nephrotoxic. However, attempts to reduce it were not found suitable for clinical use. Dietary fish oil (FO) enriched in omega-3 fatty acids reduces the severity of cardiovascular and renal diseases.

Studies on the protective effect of green tea against cisplatin induced nephrotoxicity.

Cisplatin (CP) an anticancer drug is known to induce nephrotoxicity, which limits its long-term clinical use. Green tea (GT), consumed since ancient times is known for its numerous health benefits. It has been shown to improve kidney functions in animal models of acute renal failure.

Protective effect of green tea extract on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney.

Gentamicin (GM) is an effective aminoglycoside antibiotic against severe infections but nephrotoxicity and oxidative damage limits its long term clinical use. Various strategies were attempted to ameliorate GM nephropathy but were not found suitable for clinical practice. Green tea (GT) polyphenols have shown strong chemopreventive and chemotherapeutic effects against various pathologies.