Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment.

Icaritin is an active ingredient in , which has a variety of pharmacological activities. However, the low activity of Icaritin and the unclear target greatly limit its application. Therefore, based on the structure of Icaritin, we adopted the strategy of replacing toxic groups and introducing active groups to design and synthesize a series of new analogues.

Antitumor evaluation and multiple analysis on different extracted fractions of the root of Cynanchum auriculatum Royle ex Wight.

The root of Cynanchum auriculatum (C. auriculatum) Royle ex Wight has been shown to possess various pharmacological effects and has recently attracted much attention with respect to its potential role in antitumor activity. The C-21 steroidal glycosides are commonly accepted as the major active ingredients of C.

Two new compounds from Scolopendra multidens Newport.

Two new compounds, 5β-pregnane-2α,6α,20(S)-triol (1) and 8-hydroxyl-3-methoxyl-2(1H)-quinolone (2), were isolated from Scolopendra multidens Newport. Their structures were elucidated on the basis of spectroscopic methods including 1D and 2D NMR and HR-TOF-MS.

[Studies on the chemical constituents in fruits of Acanthopanax gracilistylus].

Objective: To study the chemical constituents in the fruits of Acanthopanax gracilistylus.

Methods: The chemical components were isolated and purified by silica gel, ODS C-18, and Sephadex LH-20 column chromatogram. The chemical structures were elucidated on the basis of physicochemical properties and spectral data.

[Chemical constituents of Chinese red ginseng].

The chemical constituents of Chinese red ginseng (Panax ginseng) were investigated. The chemical constituents were isolated and purified by silca gel, ODS, and Sephedex LH-20, column chromatography, and preparative HPLC. Their chemical structures were elucidated on the basis of physicochemical properties and spectra data.

[Study on chemical constituents from Cicuta virosa var. latisecta].

Objective: To investigate the chemical constituents in Cicuta virosa var. latisecta.

Method: Many kinds of column chromatography were used to isolate the compounds from the EtOH ext.

[Detection of hepatotoxic pyrrolizidine alkaloids in Ligularia Cass. with LC/MSn].

Aim: To detect the hepatotoxic pyrrolizidine alkaloids (HPA) in the genus Ligularia Cass..

Methods: The alkaloid extracts of Ligularia plant materials were detected and analyzed by the method of combination of TLC, and LC/MSn.