Tubo-ovarian abscess: A proposed new scoring system to guide clinical management.

Objective: To create a risk scoring system comprised of clinical and radiological characteristics that can predict the likelihood of antibiotic treatment failure of tubo-ovarian abscesses. The score should guide clinicians in identifying patients to whom early intervention should be offered instead of a prolonged trial of antibiotics.

Methods: A multicenter, retrospective cohort study carried out between January 1, 2013 and September 30, 2019, identified consecutive patients with tubo-ovarian abscess.

Pulmonary arteriovenous malformation unmasked in pregnancy: A case report.

Pulmonary arteriovenous malformations are anomalous communications between arteries and veins of the pulmonary vasculature. Its incidence is rare. Pulmonary arteriovenous malformations can be asymptomatic or cause profound cardiovascular compromise and adverse neurological sequelae, as a result of right to left shunting of deoxygenated blood.

Phenytoin but not valproate directly affected in vitro trophoblast differentiation.

Objective: Epilepsy has been associated with poor obstetric outcomes that could be the result of the epilepsy itself or a direct effect of anti-epileptic medication on placentation. The aim of this study was to investigate any direct effect of anti-epileptic drugs on an established, in vitro bioassay of trophoblast differentiation.

Study Design: Primary extravillous trophoblast cells were cultured in the presence of phenytoin and sodium valproate at a range of concentrations with appropriate solvent controls.

Trophoblast invasion.

Trophoblast invasion can be seen as a tightly regulated battle between the competing interests of the survival of the fetus and those of the mother. Successful pregnancy is dependent on the trophoblast invading the mother, attaching the pregnancy to the uterus and securing an adequate supply of oxygen and nutrient to the fetus. For successful invasion to occur, extravillous trophoblast has to perform a range of functions; transformation of the maternal spiral arteries, tolerate hypoxia, proliferate and die by apoptosis (programmed cell death), differentiate, adhere to and digest the extracellular matrix, move and interact with the maternal immune system.