Publications by authors named "Shea P O'Connell"
Objective: To assess gender, ethnicity, and deprivation-based differences in provision of aortic valve replacement (AVR) in England for adults with aortic stenosis (AS).
Methods: We retrospectively identified adults with AS from the English Hospital Episode Statistics (HES) between April 2016 and March 2019 and those who subsequently had an AVR. We separately used HES-linked Clinical Practice Research Datalink (CPRD) to identify people with AVR and evaluate the timeliness of their procedure (CPRD-AVR cohort).
Article Synopsis
- Scientists are studying urine as a way to find out if someone has prostate cancer without needing surgery or anything invasive.
- They looked at urine samples from 76 men and found different cancer-related genes in parts of the urine, specifically in tiny vesicles (EVs) and in cells (Cells).
- The research showed that some genes are better at detecting cancer in EVs, while others are better in Cell samples, suggesting it’s a good idea to separate the urine into these parts before testing for cancer.
There is a clinical need to improve assessment of biopsy-naïve patients for the presence of clinically significant prostate cancer (PCa). In this study, we investigated whether the robust integration of expression data from urinary extracellular vesicle RNA (EV-RNA) with urine proteomic metabolites can accurately predict PCa biopsy outcome. Urine samples collected within the Movember GAP1 Urine Biomarker study (n = 192) were analysed by both mass spectrometry-based urine-proteomics and NanoString gene-expression analysis (167 gene-probes).
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