[The use of radiopharmaceuticals for myocardial perfusion in oncological diagnosis].

Recently, radiopharmaceutics for myocardial perfusion are widely used in oncological diagnosis, not merely supplementing the other methods of examination, but having also an independent role both in terms of making exact diagnosis, and in evaluating the diffusion of malignant tumors, as well as in estimating the results of the therapy undertaken. Their widespread implementation in practice is still not well enough studied, and awaits further clarification.

[Radionuclide ventriculography in the diagnosis of a postinfarct aneurysm and the evaluation of its impact on left ventricular function].

This is a report on thirty-four patients subjected to radionuclide ventriculography because of suspected post-infarction aneurysm. To discover eventual kinetic disorders, apart from visual assessment of the wall kinetics, amplitude-phase analysis is also employed. The sensitivity of the method is compared with that of bi-dimensional echocardiography.

[Radionuclide ventriculography for the diagnosis of postinfarct aneurysm and the assessment of its impact on left ventricular function].

Radionuclide ventriculography was performed in 34 patients suspected of having postinfarction aneurysm. In addition to visual appraisal of wall kinetics, amplitude-phase analysis was used for detecting kinetic disorders. The sensitivity of the method was compared with that of two-dimensional echography, and postinfarction left ventricular function was assessed by the two methods.

[133Xe (xenon) study of pulmonary ventilation and perfusion with a gamma camera].

Pulmonary ventilation and perfusion on regional level was measured by determining the distribution and elimination of introduced by inhalation 133He-gas, accordingly of intravenously injected 133He-solution. Fifty seven patients 7 to 60 years of age were included in the study, distributed by diagnoses, as follows: pulmonary thromboembolism 24 patients, 16 children with recurrent bronchopneumonia, pneumonia 10, central lung cancer 4, lung echinococcus 2 and one patient with LTE associated with chronic obstructive lung disease. All had ventilatory and subsequent perfusion dynamic scintigraphy.

[Volumetric indices of the left ventricle in patients with ischemic heart disease].

In addition to the conventional indices of radionuclide angiography with ECG-gait in equilibrium, the authors determined the volume indices of the left ventricle at rest by the so-called nongeometric method in 30 patients with ischemic heart disease. Patients without myocardial infarct (13 subjects) had decreased total left-ventricular ejection fraction (EF), as a result of increase in the end systolic volume index (ESVI) in one of the tested patients. Changes in the regional fractions and in the wall kinetics were detected in 6, resp.

[Radiocardiographic assessment of hemodynamics in different types of acquired heart valve defects].

The hemodynamic disorders in various types of cardiac defects were studied in 133 subjects, 82 of them patients with aquired combined valvular defects of the heat and the results obtained were juxtaposed. The hemodynamics was determined by the method of quantitative radiocardiography (QRCG). The volume of circulating blood was determined as well as the indices of cardiac output, ventricular, pulmonary quantities and the indices of aortic route.

[Radiocardiographic evaluation of the hemodynamics in combined acquired heart defects].

One hundred and twenty eight subjects were examined, 77 of them with acquired combined valvular defects, with an average age of 42,2 as well as 51 healthy subjects. Depending on the degree of cardiac insufficiency, the patients were grouped into three stages, I, II A and II B. The hemodynamics was studied by quantitative radiocardiography.

[Functional radioisotope diagnosis in myocardial infarct].

The general and regional hemodynamics was studied in 50 patients with clinical, paraclinical and electrographic data on myocardial infarction in chronic and subacute stage via quantitative radiocardiography (ECG) and via the determination of the total coronary output (TCO). A significant reduction was radiocardiographically established of the indices of cardiac output as well as of the ejection fractions of the right and left ventricles, a manifestation of disturbed contractility of myocardium. TCO was substantially reduced (49.

Determination of aortic distensibility and its variations in arterial hypertension.

Aortic distensibility has been determined by non-invasive techniques: radioisotope measurement, quantitative radiocardiography and indirect arterial pressure measurement with calculation of the aortic rigidity index by the formula D = PP pulse (mm or mercury) / stroke volume (ml). The index value, equalling in normotensive subjects D = 0.55 was quite close to the value obtained in haemodynamic laboratories by invasive techniques (intracardiac stroke volume and arterial pressure measurements).

[201T1 study of regional myocardial perfusion using a gamma counter and the EC1020 computer].

Myocardial perfusion was followed up after 500-1000 muCi 201TI-chloride injection at a gamma camera Pho-Gamma HP, Nuclar, Chicago with 4060 channel analyser and the images, according to the programmes of the authors, were processed with a computer type EC 1020. Some of the patients were examined by removing the detector, aiming at magnifying of the image and enhancing the differentiation ability under I cm. In some borderline cases, the patients were examined under physical loading and at rest for the differentiation of the normal from the disperfusion myocardial zones.

[Radioisotopic functional diagnosis in uncomplicated hypertension].

General hemodynamics of 70 patients with hypertonic disease was determined as well as the regional hemodynamics in 22 of them via radio-isotope methods, quantitative radiocardiography (QRCG) and determination of the total coronary output (TCO). Statistically significant decrease of circulating blood volume was radiocardiographically determined as well as increase of stroke volume and ventricular volumes and the indices of post-loading--general peripheral vascular resistance, index of aortic rigidity. The total coronary output is increased in patients with and without manifestations of left ventricular hypertrophy resulting from increased diastolic perfusion pressure.

[Comparative evaluation of the cardiac stroke and minute volumes by impedance cardiography and radiocardiography].

In 32 health subjects and 33 patients, mainly with acquired heart defects, the indices of central hemodynamics were determined, namely -- stroke and minute volume and their indices via impedance-cardiographic and radiocardiographic methods. A very good correlation was established between those indices, obtained via both methods. Impedance-cardiography is concluded to be a very convenient easily applicable method in determining cardiac hemodynamics, both in healthy subjects and cardiac patients with acquired heart defects.

[Electrocardiographic changes and hemodynamic comparisons in arterial hypertension].

The electrocardiographic criteria for left-ventricular loading were studied in patients with non-complicated arterial hypertension and were juxtaposed to the basic hemodynamic indices, determined via radio-isotope method--quantitative radiocardiography. Regular changes in the hemodynamics and electrocardiographic criteria were found, in the initial phases within the limits of the norm, and in the later ones--exceeding it. The method of correlation analysis was applied between the separate hemodynamic indisec and electrocardiographic criteria for left ventricular loading both in the separate subgroups and for the whole group.

[Comparative evaluation of the radiocardiographic and the dye dilution methods of determining cardiac output and circulating blood volume].

The authors compared the radiocardiographic and dye-dilution methods for hemodynamics determination. Cardiac capacity and volume of circulating blood were determined in 42 patients with atherosclerotic myocardiosclerosis and acquired valvular defects. A very high correlation dependence was established between the two methods.