[Assessment of the safety and efficacy of medicinal product PPR-001 based on regulatory polypeptides of the testes].

Objective: Evaluation of the effectiveness and safety of the drug PPR-001 (lyophilizate) in comparison with placebo in men with impaired spermatogenesis.

Materials And Methods: This study was a randomized, double-blind, placebo-controlled, prospective, multicenter, parallel-group research.

Results: It was found that the drug has clinical efficacy and a positive effect on the concentration of spermatozoa in the ejaculate, the percentage of progressively mobile forms and the number of morphologically normal forms of spermatozoa was increased in the group of PPR-001.

Design optimization for bright electrically-driven quantum dot single-photon sources emitting in telecom O-band.

A combination of advanced light engineering concepts enables a substantial improvement in photon extraction efficiency of micro-cavity-based single-photon sources in the telecom O-band at ∼1.3 µm. We employ a broadband bottom distributed Bragg reflector (DBR) and a top DBR formed in a dielectric micropillar with an additional circular Bragg grating in the lateral plane.

Wavelength-stabilized near-field laser.

Surface-trapped electromagnetic waves can be localized at a boundary between a semiconductor distributed Bragg reflector (DBR) and a homogeneous dielectric medium or air. These waves enable a novel class of in-plane-emitting optical devices including edge-emitting lasers, disk microlasers or near-field fiber-coupled lasers. We show that the surface-trapped modes can be controlled by tuning the thickness of a single DBR layer.

Virtual cavity in distributed Bragg reflectors.

We show theoretically and experimentally that distributed Bragg reflector (DBR) supports a surface electromagnetic wave exhibiting evanescent decay in the air and oscillatory decay in the DBR. The wave exists in TM polarization only. The field extension in the air may reach several wavelengths of light.

Room-temperature yellow-orange (In,Ga,Al)P-GaP laser diodes grown on (n11) GaAs substrates.

We report room temperature injection lasing in the yellow-orange spectral range (599-605 nm) in (AlGa)InP-GaAs diodes with 4 layers of tensile-strained InGaP quantum dot-like insertions. The wafers were grown by metal-organic vapor phase epitaxy side-by-side on (811), (211) and (322) GaAs substrates tilted towards the <111> direction with respect to the (100) surface. Four sheets of GaP-rich quantum barrier insertions were applied to suppress leakage of non-equilibrium electrons from the gain medium.

Anti-waveguiding vertical-cavity surface-emitting laser at 850 nm: From concept to advances in high-speed data transmission.

Oxide-confined vertical cavity surface emitting lasers (VCSELs) with anti-waveguiding AlAs-rich core presently attract a lot of attention. Anti-waveguiding cavity enables the maximum possible optical confinement of the VCSEL mode ("λ/2 design"), increases its oscillator strength and reduces dramatically the optical power accumulated in the VCSEL mesa regions outside the aperture. VCSEL designs are suggested that favor single transverse mode operation.

[Leiomyosarcoma of soft tissues. Clinical characteristic and results of treatment].

Clinical characteristics of leiomyosarcoma of soft tissues and results of treatment of patients with this pathology are presented. It was revealed that the peak of incidence was in the age group 5O-69 years. There was showed the priority of surgery, as the only method of treatment, and in the combined regimen with the overall five-year survival of 43,2% and 33,3% respectively.

Formation of three-dimensional islands in subcritical layer deposition in Stranski-Krastanow growth.

A new method for the formation of three-dimensional (3D) strained islands in lattice-mismatched (B on A) heteroepitaxy is proposed. Once B forms a wetting layer of a subcritical thickness, material C is deposited, which is lattice matched to A and does not wet B. Then B and C phase separate forming local B-rich and C-rich domains on the surface.

[Pharmacokinetics of fentanyl during sevoflurane based general anesthesia in children].

The research is based on the analysis of 50 cases of anesthesia during reconstructive surgeries in children. The anesthesia was based on inhalation of sevolflurane and injection of fentanyl by the bolus infusion scheme. During the different stages of anesthesia the opioid concentration in plasma was measured.

Influence of mineral components on laser-induced fluorescence spectra of calcified human heart-valve tissues.

Laser-induced fluorescence (LIF) spectra of calcified human heart-valve tissue and LIF spectra of macroscopic calcinosis fragments dissected from human heart valves were compared with LIF spectra of pig myocardium tissues. Excitation was provided by an excimer laser with wavelength lambda = 248 nm. Fluorescence bands that were due to mineral and organic tissue components were identified by measurement of LIF spectra of macroscopic fragments of calcified tissues that had been heat treated at 700 degrees C.

[Role of palliative surgery in complex treatment for disseminated breast cancer].

An assessment was undertaken of survival and prognosis in 30 patients with primary disseminated breast tumors which disintegrated following palliative mastectomy carried out for sanitary purposes. That resulted in significant improvement in general condition, higher hemoglobulin and lowered intoxication which in turn made medication and radiotherapy possible: chemotherapy (4-6 cycles) followed by hormonal therapy (22-73.3%), hormonal therapy (8-26.

[Central and cerebral hemodynamics during gynecological laparoscopic interventions in children].

The authors examined central and cerebral hemodynamics in children during gynecological laparoscopic interventions. The course of 64 anesthesias was analyzed in girls aged 3 to 16 years, who had undergone laparoscopic surgery. Central hemodynamics was studied by tetrapolar rheography on a Diamant apparatus; cerebral oximetry was examined on a Critikon RedOx Monitor 2020 device.

[Effect of volatile inhalational anesthetics on cerebral blood volume and oxygen status in children].

The investigation evaluated the effect of various volatile anesthetics on cerebral blood volume and oxygen status in sick children at the stage of anesthesia induction. Ninety-two children were distributed into 3 groups: Groups 1 (n = 36) and 2 (n = 24) underwent stepwise induction with halothane and enflurane, respectively. Group 3 (n = 32) had vital capacity rapid inhalation induction with sevoflurane.

Submonolayer quantum dots for high speed surface emitting lasers.

We report on progress in growth and applications of submonolayer (SML) quantum dots (QDs) in high-speed vertical-cavity surface-emitting lasers (VCSELs). SML deposition enables controlled formation of high density QD arrays with good size and shape uniformity. Further increase in excitonic absorption and gain is possible with vertical stacking of SML QDs using ultrathin spacer layers.

Tunable metastability of surface nanostructure arrays.

A Fokker-Planck equation is used to model the coarsening of surface nanostructure arrays. Metastable states are identified which are associated with a narrow size distribution and a coverage dependent mean island size. This is a general feature linked to nanostructures which, as a function of island size, are associated with a minimum in formation energy per atom and a positive chemical potential gradient.

Metastability of ultradense arrays of quantum dots.

We present a linear stability analysis of ultradense arrays of coherently strained islands against Ostwald ripening. Surprisingly, short-range elastic interactions are found to overcome the destabilizing contribution of surface energy, leading to a metastable array of quantum dots. Simulations of Ostwald ripening kinetics directly verify the existence of this metastable regime and confirm the nature of the most unstable mode for subcritical island coverage.

Self-assembled quantum dots: crossover from kinetically controlled to thermodynamically limited growth.

By means of kinetic Monte Carlo simulations of the self-organized growth of quantum dots in strained semiconductor systems we resolve the seemingly contradictory features of kinetic versus thermodynamic behavior, e.g., with respect to the temperature dependence of the average dot size and their dispersion.

[Components of anesthesiological provision and central hemodynamics in hypothermia without perfusion].

Central hemodynamics was studied by thermodilution in 16 patients with acquired mitral defect during surgery under conditions of hypothermia without perfusion. Cooling and surgical correction were carried out under superficial ether anesthesia with morphine and droperidol. A 28% decrease of the minute circulation volume is observed as early as under general anesthesia and at the very beginning of cooling (10.

[The complications of open mitral commissurotomy under moderate hypothermia].

A comparative assessment of the postoperative period in 212 patients was made. Open mitral commissurotomy was performed under conditions of hypothermia without perfusion. Operations were fulfilled on 82 patients under conditions of craniocerebral hypothermia (the first group of patients, lethality 3.

[The low cardiac output syndrome after valve-conserving operations under hypothermia without perfusion].

Under study were the frequency of occurrence and causes of development of the syndrome of low cardiac output after the saving correction of mitral defects under conditions of cranio-cerebral (1st group-80 patients), general moderate (2nd group-130 patients) and deep hypothermia (open mitral commissurotomy-3rd group of 134 patients and reconstructive operations on the mitral valve-4th group of 104 patients). Frequency of development of the complication was reliably higher in groups with deep hypothermia (1.25% of patients in the 1st group, 9.