[Quality of life of patients with multiple sclerosis in the Smolensk region].

Objective: To study the quality of life (QoL) of patients with multiple sclerosis (MS) in the Smolensk region who receive MS disease-modifying therapies (DMT).

Material And Methods: The study included 37 patients receiving MS DMT. The 36-Item Short Form Health Survey (SF-36), the Multiple sclerosis Quality of Life (MusiQol), the Hamilton Depression Rating Scale, a scale of satisfaction with treatment, the Fatigue Severity Scale were administered.

Resonant electron capture by polycyclic aromatic hydrocarbon molecules: Effects of aza-substitution.

Resonant electron capture by aza and diaza derivatives of phenanthrene (7,8-benzoquinoline and 1,10-phenanthroline) and anthracene (acridine and phenazine) at incident free electron energies (Ee) in the range of 0-15 eV was studied. All compounds except 7,8-benzoquinoline form long-lived molecular ions (M-) at thermal electron energies (Ee ∼ 0 eV). Acridine and phenazine also form such ions at epithermal electron energies up to Ee = 1.

Resonant electron capture by 5-Br-2'-deoxyuridine.

The results of the study of resonant electron capture by molecules of 5-Br-2'-deoxyuridine (BrdUrd) over the range of electron energies from near zero to 14 eV are described. In the thermal energy range, long-lived molecular negative ions, unstable with respect to autoneutralization and dehalogenation, have been registered. Examination of the kinetics of these decay processes led us to the conclusion that the most probable structure for molecular negative ions is that with an extended C-Br bond, which was predicted earlier using quantum-chemical calculations.

A unified statistical RRKM approach to the fragmentation and autoneutralization of metastable molecular negative ions of hexaazatrinaphthylenes.

For the compounds promising for use as n-type semiconductors in organic electronics and energy storage devices, hexaazatrinaphthylene (HATNA) and its derivative hexamethoxy-hexaazatrinaphthylene (HMHATA), the monomolecular processes occurring under the exposure of molecules to low-energy (0-15 eV) free electrons were studied by means of resonant electron capture negative ion mass spectrometry. Resonant electron attachment results in the formation of eminently long-lived molecular negative ions (MNIs) in an abnormally wide range of incident electron energy (E) from 0 to 5-7 eV. For both compounds, this observation serves as an indication of the strong electron-accepting properties and high stability of MNIs against electron autodetachment.

Resonant electron capture by uridine and deoxyuridine molecules: Fragmentation with charge transfer.

Rationale: Charge transfer via DNA plays an important role in physical and chemical processes in biological systems, and is used in biomolecular electronics. The present study considers the resonant interaction of free electrons with nucleosides, which is important for an understanding of the processes of electron transport in DNA.

Methods: Resonant electron capture negative ion mass spectrometry was used to study the processes of low-energy electron attachment to two uracil nucleosides, uridine and deoxyuridine, while density functional theory (DFT) calculations were used to analyze the energy aspects of ion formation and decay.

Negative ions, molecular electron affinity and orbital structure of cata-condensed polycyclic aromatic hydrocarbons.

Rationale: Polycyclic aromatic hydrocarbons are molecules of ecological, astrochemical significance that find practical applications in organic electronics, photonics and the chemical synthesis of novel materials. The utility of these molecules often implies the occurrence of their ionized forms. Studies in the gas phase of elementary processes of energy-controlled interaction of molecules with low-energy electrons shed light on the mechanisms of transient negative ion formation and evolution.

Resonant electron capture by aspartame and aspartic acid molecules.

Rationale: The processes for dissociative electron capture are the key mechanisms for decomposition of biomolecules, proteins in particular, under interaction with low-energy electrons. Molecules of aspartic acid and aspartame, i.e.

Electron ionization and dissociation of aliphatic amino acids.

We present experimental and theoretical study of electron ionization and dissociative ionization to the gas phase amino acids valine, leucine, and isoleucine. A crossed electron/molecular beams technique equipped with quadrupole mass analyzer has been applied to measure mass spectra and ion efficiency curves for formation of particular ions. From experimental data the ionization energies of the molecules and the appearance energies of the fragment ions were determined.

Study of fragmentation pathways of metastable negative ions in aliphatic dipeptides using the statistical theory.

Rationale: Dipeptide molecules are good model systems for investigation of resonant reactions of low-energy electrons with proteins. The present work is devoted to the study of the processes of formation and fragmentation of negative ions in aliphatic dipeptides glycyl-glycine and glycyl-alanine. The metastable decays of negative ions were detected in these objects, and have been investigated with the aim of clarification of the mechanisms of fragmentation.

Dissociative electron attachment to glycyl-glycine, glycyl-alanine and alanyl-alanine.

The processes of negative ions formation of dipeptides glycyl-glycine, glycyl-alanine and alanyl-alanine in the conditions of resonant electron capture have been studied with a help of negative ions mass spectrometry. Using a thermochemical approach, the main channels of fragment negative ions formation were found and the structure of the ions were established. The isobaric ions have been identified by the experiments with high mass resolution.

High resolution mass analysis of N- and C-terminal negative ions resulting from resonance electron capture by aliphatic amino acids.

High mass resolving power was applied to study resonance electron capture by glycine, alanine, and valine, and accurate mass measurements helped to distinguish between some negative ions having the same nominal masses. It was established that the C- and N-terminal negative ions of the same nominal masses were formed at different electron energies from different resonance states. The typical fragmentation pathways in deprotonated amino acids via loss of water initiated by collisional activation were not observed upon resonant electron capture by aliphatic amino acids.

Specific formation of negative ions from leucine and isoleucine molecules.

Dissociative electron attachment (DEA) to gas phase leucine (Leu) and isoleucine (Ile) molecules was studied using experimental and quantum-chemical methods. The relative partial cross sections for DEA have been measured using crossed electron/molecular beams technique. Supporting ab initio calculations of the structure, energies of neutral molecules, fragments, and negative ions have been carried out at G3MP2 and B3LYP levels in order to interpret the experimental data.

Rearrangement and predissociation processes in negative molecular ions of nitrobenzenes.

The reactions of resonant electron capture by the molecules of benzene nitroderivatives has been studied in the gas phase. Some fragment negative ions were found to be unstable with respect to electron autodetachment. This circumstance has been used for the determination of their structure.

Genotypological method of analysis of individual responsiveness of an organism in experiment.

The principle of a genotypological method of analysis of individual responsiveness of an organism in experiment is formulated on the basis of data in the literature and the results of the author's own investigations. The main objective of a genotypological method is the determination of the constitutional typological features of responsiveness and their markers on the basis of similar or different norms of reaction and paratypical factors. It is proposed that individual responsiveness in a population be determined by way of disclosing in individuals the corresponding markers previously established in linear and non-linear animals in experiment, while observing a number of necessary conditions.

[Genotypical characteristics of the immunological Vi-antibody maturation depending on the effect of Vi-antigen deposit in the body].

The authors carried out a comparative analysis of the changes in the antibody synthesis and their immunological maturation in the immunization with various doses of the Vi-antigen of linear rats differing by the capacity to deposit this antigen. August rats with a high capacity to deposit the Vi-antigen (in comparison with Wistar rats in which this capacity was less) were characterized by an increased level of highly avid antibodies. The interlinear differences were found in the character of the changes in the antibody synthesis depending on the immunizing dose of the antigen.

[Peculiarities of immunological response to the administration of Vi-antigen in patients suffering from typhoid fever and in experimental animals].

Vi-antigen parenterally administered into the organism could be revealed on erythrocytes with the aid of inhibition of erythrocyte sedimentation reaction with immune Vi-serum. Patients with typhoid fever displayed positive results in 53.8% of cases.