MORPHOLOGICAL CHANGES OF PERIODONTAL COMPONENTS UNDER EXPERIMENTAL LIPOPOLYSACCHARIDE PERIODONTITIS COMBINED WITH HYPERTHYROIDISM.

Objective: The aim: Investigate structural changes in the tissues of the periodontal complex under the condition of experimental lipopolysaccharide periodontitis combined with hyper¬thyroidism.

Patients And Methods: Materials and methods: The studies were performed on adult white male rats, which simulated periodontitis combined with hyperthyroidism. Periodontal tissues were subjected to morphological examination on the 22nd day of the experiment.

DYNAMICS OF CHANGES OF C-REACTIVE PROTEIN LEVEL IN BLOOD SERUM IN THE DEVELOPMENT AND COURSE OF EXPERIMENTAL PERIODONTITIS AND THEIR CORRECTION BY FLAVONOL.

Objective: The aim: To study the value of C-reactive protein in the experimental animals blood serum with bacterial-immune periodontitis and its correction with quercetin.

Patients And Methods: Materials and methods: Modeling of periodontitis was performed by the following method: after thiopental anesthesia (at a dose of 40 mg / kg intramuscularly) rats were fixed. A subcostal injection of 0.

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?

The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. White male 12-14 weeks old inbred rats (n=48) weighing 180-200 g were employed in the experiment. They were randomly divided into the following groups: Group I - control group, Group II - group with a model of periodontitis, Group III - group with a periodontitis in a setting of hyperthyroidism, and Group IV - group with periodontitis in a setting of hypothyroidism.

A Comparative Study of Connective Tissue Metabolism Indices in Experimental Comorbidity-Free Periodontitis and Periodontitis Combined with Thyroid Dysfunction.

Periodontal disease is a chronic bacterial infection characterized by persistent inflammation, connective tissue breakdown, and alveolar bone destruction. The current study aimed to compare the connective tissue metabolism indices in rats with comorbidity-free periodontitis and in animals with periodontitis in a setting of hyper-and hypothyroidism. 12-14-week-old inbred white male rats (n=48) were included in the experiment.

A comparative study of oral microbiocenosis structure in experimental comorbidity-free periodontitis and in periodontitis combined with thyroid dysfunction.

Unlabelled: Thyroid hormones regulate numerous metabolic processes. Therefore, any alteration in their synthesis or function has important health implications. However, limited data are available regarding the relationship between thyroid hormone imbalance and periodontal health.

CORRELATION BETWEEN CONNECTIVE TISSUE METABOLISM AND THYROID DYSFUNCTION IN RATS WITH PERIODONTITIS.

The aim of the study was to clarify mechanisms of the periodontitis development in rats with thyroid dysfunction based on a comparative analysis of the correlations between the connective tissue metabolism indices and the concentration of thyroid stimulating hormone, free thyroxine and free triiodothyronine in blood serum. 12-14-week-old inbred white male rats (n=48) were included to the experiment. They were randomly divided into the following groups: control; animals with a model of periodontitis; animals with periodontitis in a setting of hyperthyroidism; animals with periodontitis in a setting of hypothyroidism.

[Polysaccharides of xylotrophic basidiomycetes].

Physicochemical properties, composition, and structure of the polysaccharides synthesized by the fungi Lentinus edodes, Ganoderma lucidum, and Crinipellis schevchenkovi in a submerged culture were studied. It has been demonstrated that the exo- and endopolysaccharides of submerged mycelia of the fungi studied are similar to the beta-(1-->3)-D-glucans of the fruiting bodies.

[Polysaccharides of Ganoderma lucidum: factors affecting their production].

The conditions of polysaccharide production by the fungus Ganoderma lucidum were optimized. The maximal yield of endopolysaccharides and exopolysaccharides was observed at 25-30 degrees C, initial pH of culture medium 4.0-6.

[The carbohydrates of submerged mycelium of xylotrophic basidiomycetes].

It was demonstrated that the total content of carbohydrates in the submerged mycelium of xylotrophic basidiomycetes falls into the range of 34.66-57.57%.

[The nature of melanin pigments from some micro- and macromycetes].

New inhibitors of melanin formation by micromycetes Aspergillus carbonarius, Alternaria alternata, and Paecilomyces variotii and basidiomycetes Inonotus obliquus and Phellinus robustus were found. Precursors of melanin pigments were isolated and identified. p-Hydroxybenzoic acid was identified among the products of alkaline degradation of melanin formed by micromycetes, whereas in the case of macromycetes this was protocatechuic acid.

[Antioxidant activity in fungi degrading lignocellulose substrates].

Considerable differences in lignin degradation by fungi of two ecological groups have been revealed. Xylotrophs cause a twofold decrease in the molecular weight of lignin. The degrading activity of saprotrophs is insignificant.

[Antioxidant features of fungal melanin pigments].

Fungal melanin pigments were shown to display a high antioxidant activity. An increase in the number of methyl substituents in benzidine molecules of melanins obtained from micromycetes and macromycetes was accompanied by a decrease in the efficiency of inhibition of peroxidase-catalyzed oxidation. Melanins were found to have considerable gene-protecting properties.

[Melanin complex of the fungus Inonotus obliquus].

The fungus Inonotus obliquus (Pers.) Pil. synthesised high-molecular-weight phenolic pigments that were assigned to melanins according to their physicochemical properties.

[Melanin pigments of the fungi Paecilomyces variotii and Aspergillus carbonarius].

Pigments synthesized by micromycetes Paecilomyces variotii and Aspergillus carbonarius are true melanins. Copper ions and bicyclic phenolic compounds stimulated melaninogenesis, whereas benzotriazole inhibited this process. Precursors of melanin pigments were obtained and identified.

[Physiologically active substances from the fungus Coriolus hirsutus (Fr.) Quel].

The fungus Coriolus hirsutus is able to synthesize physiologically active compounds with a high antioxidant activity. The level of the antioxidant activity is mainly determined by phenolic constituents and makes up 90-95% of ionol activity. The experiments carried out in test animals have shown hypolipidemic and hypocholesterolemic effects of the fungus alcohol extract.

[The immunodiagnosis of tick-borne encephalitis by using the indirect immune rosette formation reaction].

200 patients suspected for tick-borne encephalitis (TBE) were examined by the method of the indirect immune rosette-formation test. In 70.15% of patients with the serologically confirmed diagnosis of TBE immune lymphocytes were detected as early as on day 1 of examination.