[Clinico-hemorheological aspects of the course of hypertension].

Seventy nine patients with essential hypertension were studied. Group 1 showed profound changes in hemorheological parameters, Group 2 exhibited moderate changes in this system. A more severe course of essential hypertension was found in patients from Group 1.

[An experimental model of DIC syndrome].

Disseminated intravascular coagulation syndrome (DIC-syndrome) is experimentally reproduced by introduction of 30% aqueous solution "Desoxon-3" (2800-300 mg/kg) into the organism of laboratory animals (rabbits). The preparation was perorally introduced once on an empty stomach for 1 min. Biochemical and pathomorphological studies testify to the development of the typical DIC-syndrome in rabbits.

[Changes in cerebral circulation under the influence of korinfar in hypertension patients].

A study of the characteristic changes of the cerebral blood circulation in patients with hypertensive disease after corinfar intakes indicates that the cerebral blood flow and self-feeling of the patients varied depending on the initial state of the cerebral blood flow. "Hypotonic" disorders of the cerebral blood flow are less favourable for corinfar treatment as compared with the "spastic" disturbances.

[Effect of corinfar on indicators of cerebral circulation in patients with hypertension].

Corinfar-induced changes in rheographic cerebral circulation patterns are reviewed in patients with essential hypertension. Corinfar administration was followed by a normalization of basically elevated tone of major cerebral arteries as well as minor vessels, and an improvement of arterial blood filling of the brain, in the presence of decreasing arterial blood pressure and better general condition of the patients. Low baseline arterial tone tended to rise after corinfar administration.

[Hemodynamic effects of hypotensive agents under adrenergic block in hypertension].

Examination of 94 patients with stage II hypertensive disease and 20 rabbits with hypertension showed that in the hypokinetic type of hemodynamics separate medication with dibazol, papaverin hydrochloride and reserpine caused a reduction of arterial pressure in all cases due to a decrease in total peripheral resistance. In combination with phentolamine dibazol and papaverin hydrochloride caused no further decrease of arterial pressure whereas the hypotensive effect of reserpine in this case was intensified along the type of summation of hypotensive effects due to more significant decrease in total peripheral resistance. During beta-adrenostructure blocking in patients with hyperkinetic type of hemodynamics, arterial pressure dropped due to a decrease of the cardiac output.

[Changes of catecholamine content in the myocardium in thyrotoxicosis].

Experimental thyrotoxicosis was induced in rats and rabbits. The content of catecholamines was significantly decreasing in the myocardium of rabbits in the presence of severe thyroidine-induced toxicosis. The noradrenaline concentration was especially low in the ventricles.