Parvisides A and B, new glucosides from Galinsoga parviflora.

Phytochemical investigations of the n-butanol soluble sub-fraction of the methanolic extract of Galinsoga parviflora Cav. has led to the isolation of two new glucosides named as parvisides A (1) and B (2). Their structures have been assigned on the basis of their spectral analysis including 1D and 2D NMR techniques.

Two new biisoflavonoids from the roots of Daphne oleoides.

Phytochemical investigation of the ethyl acetate soluble fraction of the methanol soluble extract of the roots of Daphne oleoides resulted in isolation and identification of two new isomeric biisoflavonoids characterized as 8,8"-bi-6-hydroxyorobol (1) and 8,8"-bi-6, 2'-dihydroxygenistein (2). The structures of these compounds were established by analysis of their 1D and 2D NMR and HRMS data.

{5-Chloro-2-[(4-chloro-benzyl-idene)-amino]-phen-yl}(phen-yl)methanone.

In the title compound, C(20)H(13)Cl(2)NO, the C=N bond adopts an E conformation. The chloro-substituted rings form a dihedral angle of 11.99 (9)° with each other and form dihedral angles of 74.

New aromatic esters from Galinsoga parviflora.

Galinosoates A-C (1-3), new aromatic esters, have been isolated from the n-hexane soluble fraction of Galinsoga parviflora. Their structures were assigned from the spectral data including IR, HR-EI-MS, 1D and 2D NMR.

Pregnane derivatives from Potentilla evestita.

A new pregnane derivative, 2,6beta,7beta-trihydroxy-4-methyl-19-norpregna-1,3,5(10)-trien-17-one, has been isolated from the ethyl acetate soluble fraction of Potentilla evestita along with a pregnane derivative, 11alpha,17alpha,21-trihydroxypregna-4,16(22)-diene-3,20-dione, that is reported for the first time as a natural product. Their structures were elucidated with the aid of 1H and 13C NMR spectra and by COSY, HMQC, HMBC and NOESY experiments.

Two new 3-C-carboxylated flavones from the rhizomes of Caragana conferta.

Confertins A (1) and B (2), new 3-C-carboxylated flavones, have been isolated from the ethyl acetate soluble fraction of the rhizomes of Caragana conferta. Their structures have been assigned on the basis of spectroscopic studies.

Mutiniside, new antioxidant phenolic glucoside from Abutilon muticum.

Mutiniside (1), new phenolic glucoside, and the flavonoidal glucoside cephacoside (2) have been isolated from the n-BuOH soluble fraction, along with lupeol (3), beta-sitosterol (4), stigmasterol (5), methyl-4-hydroxybenzoate (6), taraxacin (7), ursolic acid (8), and beta-sitosterol-3-O-beta-D-glucopyranoside (9), have been isolated from the EtOAc soluble fraction of Abutilon muticum. Compounds 2-9 are reported for the first time from this species. Compound 1 showed significant antioxidant activity while moderate inhibitory activity was observed against the enzyme lipoxygenase.

Synthesis of jasplakinolide analogues containing a novel omega-amino acid.

The synthesis of the omega-amino acid 4 is described utilizing a two-dimensional synthesis strategy combined with an enzymatic differentiation of homotopic ester groups. The amino acid 4 features two non-bonded interactions that result in conformational constraints on a cyclic construct. This amino acid was incorporated into the four macrolactams 17, 22, 31, and 37.