Publications by authors named "Shazia Samanani"
Nanotechnology is being increasingly utilised in medicine as diagnostics and for drug delivery and targeting. The small size and high surface area of nanoparticles (NPs), desirable properties that allow them to cross biological barriers, also offer potential for interaction with other cells and blood constituents, presenting possible safety risks. While NPs investigated are predominantly based on the biodegradable, biocompatible, and FDA approved poly-lactide--glycolide (PLGA) polymers, pro-aggregatory and antiplatelet effects have been reported for certain NPs.
View Article and Find Full Text PDFBACKGROUND Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as secondary adrenal insufficiency.
View Article and Find Full Text PDFScreening for inhibitors of microglia to reduce neuroinflammation.
CNS Neurol Disord Drug Targets
September 2013
Article Synopsis
- Researchers screened 1040 compounds to find inhibitors of microglia aimed at reducing neuroinflammation in multiple sclerosis (MS).
- Out of these, 123 compounds significantly lowered TNF-α levels in activated microglia, but most were found to be cytotoxic at the tested concentration.
- Spironolactone emerged as a promising candidate because it effectively reduced TNF-α without harming microglia or other CNS cells, suggesting potential for further therapeutic exploration in MS.