Large language models and generative AI in telehealth: a responsible use lens.

Objective: This scoping review aims to assess the current research landscape of the application and use of large language models (LLMs) and generative Artificial Intelligence (AI), through tools such as ChatGPT in telehealth. Additionally, the review seeks to identify key areas for future research, with a particular focus on AI ethics considerations for responsible use and ensuring trustworthy AI.

Materials And Methods: Following the scoping review methodological framework, a search strategy was conducted across 6 databases.

A Data Quality Control Method for Seafloor Observatories: The Application of Observed Time Series Data in the East China Sea.

With the construction and deployment of seafloor observatories around the world, massive amounts of oceanographic measurement data were gathered and transmitted to data centers. The increase in the amount of observed data not only provides support for marine scientific research but also raises the requirements for data quality control, as scientists must ensure that their research outcomes come from high-quality data. In this paper, we first analyzed and defined data quality problems occurring in the East China Sea Seafloor Observatory System (ECSSOS).

Potent small molecule inhibitors of spleen tyrosine kinase (Syk).

A series of oxindoles demonstrating inhibition of the phosphorylation of biotinylated substrates of Syk and IgE/Fc epsilon RI triggered basophil cell degranulation has been identified. A study of the SAR around sulfonamide 31 (IC(50)=5 nM, EC(50)=1400 nM) is discussed. The modest cellular activity representative of the sulfonamide series was overcome when the Polar Surface Area was lowered to <110 A(2), leading to the identification of amide 32 (IC(50)=145 nM, EC(50)=100 nM).

Mapping the kinase domain of Janus Kinase 3.

The utilization and impact of parallel synthesis on lead exploration around initial hit oxindole (1) are described. The emergent SAR, analogue design and functional impact will also be detailed.