Publications by authors named "Shazia Naheed"

Introduction: Global public health concerns include the emergence and spread of methicillin-resistant (MRSA) and extended-spectrum beta-lactamase (ESBL-). These pathogens cause infections that are difficult to treat, which can have fatal outcomes and require lengthy hospital stays. As a result, we created butyl 2-bromoisonicotinate and tested its antibacterial effectiveness against the ESBL- ST 405 and MRSA pathogens.

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Lactic acid bacteria are known to produce numerous antibacterial metabolites that are active against various pathogenic microbes. In this study, bioactive metabolites from the cell free supernatant of Loigolactobacillus coryniformis BCH-4 were obtained by liquid-liquid extraction, using ethyl acetate, followed by fractionation, using silica gel column chromatography. The collected F23 fraction effectively inhibited the growth of pathogenic bacteria (Escherichia coli, Bacillus cereus, and Staphylococcus aureus) by observing the minimum inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC).

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Lactic acid bacteria produce a variety of antibacterial and larvicidal metabolites, which could be used to cure diseases caused by pathogenic bacteria and to efficiently overcome issues regarding insecticide resistance. In the current study, the antibacterial and larvicidal potential of Bis-(2-ethylhexyl) phthalate isolated from BCH-1 has been evaluated. Bioactive compounds were extracted by ethyl acetate and were fractionated by gradient column chromatography from crude extract.

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Fungal infection causes deterioration, discoloration, and loss of nutritional values of food products. The use of lactic acid bacteria has diverse applications in agriculture to combat pathogens and to improve the nutritional values of cereal grains. The current research evaluated the potential of Loigolactobacillus coryniformis BCH-4 against aflatoxins producing toxigenic Aspergillus flavus strain.

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Water bodies have become polluted with heavy metals and hazardous contaminants as a result of fast development. Many strategies have been devised by researchers in order to remove hazardous contaminants from the aquatic environment. Utilizing graphene oxide-based composite materials as efficient adsorbents for waste water treatment, desalination, separation, and purification is gaining attraction nowadays.

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Fungal spoilage led to a considerable economic loss of foodstuff which ultimately affects public health due to mycotoxins production. Moreover, the consumption of commercial antifungal drugs creates side effects and develops antifungal resistance. To overcome these challenges, the current work was aimed to investigate novel antifungal cyclic dipeptide (CDP) from Lactobacillus coryniformis (Loigolactobacillus coryniformis) BCH-4.

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Background: Betti bases are pharmaceutically and synthetically important scaffolds due to their diverse range of biological activities and applications in key synthetic transformations in organic synthesis.

Objective: This work has been sought to contribute to the development, design, and implementation of an improved green methodology with higher atom economy and lower E-factor values for the synthesis of Betti bases.

Methods: To realize our objectives, we screened out different catalysts and reaction conditions using one-pot multicomponent modified Mannich reaction/Betti reaction by employing 2-naphthol, benzaldehyde and pyrrolidine as model substrates.

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A series of xanthan gum/titanium dioxide-based polyurethane elastomers were synthesized through the prepolymer method by the step growth polymerization. In the present work, xanthan gum was used as a bioactive material, with TiO as a nanofiller. The structural characterization of newly prepared polyurethane samples was carried out with the help of Fourier Transform Infrared Spectroscopy.

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In this study, we evaluated the morphological behavior of polyurethane elastomers (PUEs) by modifying the soft segment chain length. This was achieved by increasing the soft segment molecular weight ( = 400-4000 gmol). In this regard, polycaprolactone diol (PCL) was selected as the soft segment, and 4,4'-cyclohexamethylene diisocyanate (HMDI) and 1,6-hexanediol (HDO) were chosen as the hard segments.

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The current investigation was designed to remove halosulfuron methyl from aqueous media by means of neem seed powder (NSP) in batch modes. Characterizations of NSP were carried out by using EDX, SEM, FTIR, point of zero charge and surface analysis. Optimum operation conditions were scrutinized by studying the influence of different factors like solution pH, dose of NSP, contact time, initial halosulfuron methyl concentration and temperature.

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Fukuyama reaction for the synthesis of multifunctional aldehydes, secondary amines and ketones has gained considerable importance in synthetic organic chemistry because of mild reaction conditions. The use of thioesters in both Fukuyama aldehydes and ketones synthesis is highly attractive for organic chemists as they are easily accessible from corresponding carboxylic acids. Fukuyama-Mitsunobu reaction utilizes 2-nitrobenzenesulfonyl (Ns) for the protection/activation/deprotection of primary amines to afford secondary amines in good yields and high enantioselectivities.

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Lactic acid bacteria (LAB) can synthesize antimicrobial compounds (AMCs) with nutritional and bioprotective properties in crops and food products. In the current study, AMCs of BCH-4 were evaluated to control fungal spoilage in maize grains. On maize grains treated with 75%-100% (/) concentrated AMCs, no fungal growth was observed even after 72 h of inoculation.

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Organic reactions under green conditions have become popular day by day because of increased use of harmful chemicals leading to environmental hazards. This review focuses the implementation of green chemistry in Suzuki-Miyaura, Heck, Stille and Chan-Lam cross-coupling reactions incorporating a variety of strategies in which ionic liquids, water and microwave irradiations are extensively used.

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