Molecular docking, DFT analysis, and dynamics simulation of natural bioactive compounds targeting ACE2 and TMPRSS2 dual binding sites of spike protein of SARS CoV-2.

The scientific community is continuously working to discover drug candidates against potential targets of SARS-CoV-2, but effective treatment has not been discovered yet. The virus enters the host cell through molecular interaction with its enzymatic receptors i.e.

Health anxiety among medical students: A comparison between preclinical and clinical years of training.

Objective: It is common among medical students to falsely attribute bodily sensations/symptoms and holds a belief of having a medical illness with varying level of conviction. We studied and compared this condition known as "medical student syndrome", a type of hypochondriasis, between preclinical and clinical years students.

Methodology: This research was a descriptive study where a total of 100 students were approached and were asked to complete a short form of health anxiety inventory (SHAI) which has Cronbach's alpha 0.

A Comparative Study of Yoga with Paroxetine for the Treatment of Premature Ejaculation: A Pilot Study.

Context: Premature ejaculation (PME) is a common sexual disorder. Drugs used commonly used for its treatment have various side effects and disadvantages. Yoga is being increasingly studied in a variety of medical disorders with positive results.

Primary care physician's approach for mental health impact of COVID-19.

As the world struggles to control coronavirus infection with the exhausting capacity of health care systems globally, the role of primary care physician and family physician becomes more important as the first point of contact with the community. Limited availability of mental health services in India requires general practitioners to deal with psychological disorders arising due to infection outbreak and its restrictive control strategies. This article discusses what and how primary physicians can manage the psychological burden of a pandemic, and therefore, reducing the reliance on mental health specialist.

Traumatic experiences and dissociation in patients with conversion disorder.

Objective: To explore the association between childhood trauma and dissociation in patients of conversion disorder.

Methods: The cross-sectional study was conducted in Lahore, Pakistan, from April to December 2016, and comprised female patients aged 18-40 years diagnosed with conversion disorder at three major public hospitals of the city. Urdu version of symptom checklist for conversion disorder, the dissociative experiences scale and traumatic experiences checklist were used to measure study variables.

Nusinersen: The First Option Beyond Supportive Care for Spinal Muscular Atrophy.

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by degeneration of spinal motor neurons and poses significant adverse outcome in affected population. Survival motor neuron 1 (SMN1) protein encoded by SMN1 gene located on 5q is critical for survival and functioning of motor neurons. Almost identical gene SMN2, present on the same chromosome, produces a small truncated protein (SMN2) because of skipping of exon 7 from translation due to translation silent C6U substitution in exon 7 of SMN2 pre-mRNA transcript.

Psychological problems among women with infertility problem: a comparative study.

Objective: To explore the difference between anxiety and depression among infertile and fertile women.

Methods: The study was conducted in 2009 and comprised fertile and infertile women. The sample of infertile women was drawn from the Liaquat National Hospital, Patel Hospital, Infertility Concept and Zainub Hospital, located in urban areas of Karachi, while fertile women were drawn from the general population in urban Karachi.