Publications by authors named "Shaza W Shantier"

While mankind is still dealing with the COVID-19 pandemic, a case of monkeypox virus (MPXV) has been reported to the WHO on May 7, 2022. Monkeypox is a viral zoonotic disease that has been a public health threat, particularly in Africa. However, it has recently expanded to other parts of the world, so it may soon become a global issue.

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Introduction: Natural products play a pivotal role in innovative drug discovery by providing structural leads for the development of new therapeutic agents against various diseases.The present study aims to focus on the assessment of the therapeutic potential of antidiabetic phytoconstituents which were identified and isolated from the extracts of Lam, a medicinal plant traditionally used for various pharmacotherapeutic purposes.

Method: The physicochemical and pharmacokinetic parameters of the previously isolated thirty eight compounds were predicted using SwissADME web tool whereas OSIRIS Property Explorer was used for toxicity risk assessment and drug- likeliness.

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Background: A new endemic disease has spread across Wuhan City, China, in December 2019. Within few weeks, the World Health Organization (WHO) announced a novel coronavirus designated as coronavirus disease 2019 (COVID-19). In late January 2020, WHO declared the outbreak of a "public-health emergency of international concern" due to the rapid and increasing spread of the disease worldwide.

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Background: Nipah belongs to the genus and the . It is an endemic most commonly found at South Asia and has first emerged in Malaysia in 1998. Bats are found to be the main reservoir for this virus, causing disease in both humans and animals.

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Background: Chemotherapy as a science began within the 1st decade of the twentieth century with understanding of the principles of selective toxicity, the particular chemical relationships between microorganism pathogens and medicines, the event of drug resistance, and also the role of combined medical aid.

Objectives: This review aims to highlight the characteristics, specifically the pharmacokinetic parameters and the analytical methods reported in literature for the determination of Cefquinome, a fourth generation cephalosporine used to treat Gram-positive and Gram-negative caused infections.

Conclusion: Analysis of such drugs, whether used for the treatment of human or animal illness, is essential in understanding the bioavailability and therapeutic control which will ensure their activity and safety.

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The degradation behavior of cefquinome sulphate in alkaline medium at different temperatures was investigated using both first derivative spectrophotometric and HPLC methods. The drug degradation was found to be pH and temperature dependant. The pH-rate profile indicated a first order dependence of Kobs on [OH(-)] at pHs ranging between 9 and 11.

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