Publications by authors named "Shaza Sayed Ahmed"
Background: While NTRK fusion-positive cancers can be exquisitely sensitive to first-generation TRK inhibitors, resistance inevitably occurs, mediated in many cases by acquired NTRK mutations. Next-generation inhibitors (e.g.
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- The study analyzed the immune response of individuals vaccinated with the SARS-CoV-2 spike mRNA vaccine, examining both polyclonal antibodies and monoclonal antibodies (mAbs) from plasmablasts.
- Results showed that vaccinated individuals produced strong polyclonal antibody responses that could equal or surpass those from natural infections, with a higher ratio of binding to neutralizing antibodies in vaccinated individuals.
- Importantly, many vaccine-induced mAbs lacked neutralizing activity, with findings indicating effective neutralization potential primarily coming from certain RBD-binding mAbs, particularly against variants with specific mutations like E484K.