Publications by authors named "Shaylan Govind"
Introduction: Endoscopic full-thickness resection (EFTR) with an over-the-scope full-thickness resection device is a relatively new technique for the resection of colorectal lesions. Multiple centers have published the results of case series and observational cohorts regarding the use of this technique for managing difficult polyps. This study aims to aggregate the results of these studies to determine the effectiveness and safety of this technique in the resection of these technically challenging colonic lesions.
View Article and Find Full Text PDFBackground: There is limited literature on the risk of venous thromboembolism (VTE) in emergency general surgery (EGS) patients. We undertook this study to identify the rate of symptomatic VTE for patients undergoing EGS operations.
Methods: We conducted a retrospective cohort study evaluating EGS patients who underwent operative intervention between March and December 2014.
The creation of an intestinal pouch following total gastrectomy is exceedingly rare in infants. We present the case of a term infant who underwent a near-total gastrectomy on day 2 of life for diffuse gastric necrosis with perforation due to severe hypoxemia from an intrapartum nuchal cord. Gastrointestinal continuity was restored at 5 months of age with a Hunt-Lawrence pouch.
View Article and Find Full Text PDFBackground: We hypothesized that patients living in rural neighborhoods experience delayed access to surgical services manifesting in increased appendiceal perforation rates in cases of appendicitis.
Methods: This population-based cohort study included adult patients with acute appendicitis in Canada (excluding Quebec) between April 2008 and March 2015. The main outcome of interest was rate of perforation.
Background: The objective of our study was to identify the most common mechanisms of injury leading to death in our pediatric population.
Methods: A retrospective cohort of fatally injured children 0-17 years old treated at our trauma center during 2000-2015.
Results: The mortality rate in our population was 8% (n = 103).
Article Synopsis
- Patients with diverticulitis can develop hepatic abscesses due to infection spreading through the blood, and while hepatic abscesses are common, progression to a hepato-bronchial fistula is rare, making this case noteworthy.
- The case involves a 61-year-old man suffering from significant health issues, including weight loss and breathing difficulties, along with complications like pleural effusion and lung abscesses, tied back to a history of diverticulitis.
- Medical intervention included drainage of the abscess and a surgical procedure to remove inflamed tissue, ultimately leading to the patient’s recovery and safe discharge after treatment.
Article Synopsis
- Prostate tumours show diverse responses to treatment, and current prognostic factors only account for some of this variation, prompting further investigation into their genetic profiles.* -
- Analysis of 200 whole-genome and 277 whole-exome sequences revealed that localized, non-indolent tumours lack key mutations found in metastatic cases, instead featuring non-coding changes and large-scale rearrangements.* -
- Many genetic abnormalities were linked to disease recurrence, and a new signature of these abnormalities was found to be more effective than established biomarkers, suggesting that targeted treatments could enhance cure rates for aggressive localized prostate cancer.*
Article Synopsis
- Researchers studied 74 patients with a type of prostate cancer called Gleason score 7 to understand how different parts of their tumors were unique.
- They looked closely at 5 patients by analyzing 23 specific areas of their tumors and found lots of differences in the cancer's genetic makeup.
- A new gene called MYCL was found to be important, and this study helps doctors predict how a patient's cancer might behave, which could lead to better treatments in the future.
Background: Chromothripsis, a newly discovered type of complex genomic rearrangement, has been implicated in the evolution of several types of cancers. To date, it has been described in bone cancer, SHH-medulloblastoma and acute myeloid leukemia, amongst others, however there are still no formal or automated methods for detecting or annotating it in high throughput sequencing data. As such, findings of chromothripsis are difficult to compare and many cases likely escape detection altogether.
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