Publications by authors named "Shayany Pinto Felix"
Article Synopsis
- The study investigated the genetic diversity of HPV16 lineages and their carcinogenic risks in women with cervical conditions in northeast Brazil.
- By analyzing 196 cases over two years, researchers compared HPV16 variants in cervical intraepithelial neoplasia (CIN2/CIN3) and cervical cancer.
- Results indicated that while lineage A was commonly found in both conditions, lineage D was significantly more frequent in cervical cancer, suggesting it may be linked to a higher cancer risk.
Article Synopsis
- * The study aimed to investigate the relationship between E5 protein expression in HPV16 and HPV18 cervical tumors and the levels of EGFR and VEGFA as well as patient survival rates.
- * Results indicated no significant correlation between E5 transcript presence and EGFR or VEGFA levels, nor between E5 expression and overall survival for patients with advanced HPV16 squamous cell carcinoma.
Objectives: To compare and describe type-specific characteristics of HPV16, HPV18 and HPV45 in cervical cancer with respect to 3'LCR methylation and disruption of E1/E2.
Methods: The methylation level of 137 cervical cancer samples (70 with HPV16, 37 with HPV18, and 30 with HPV45) of Brazilian patients was analyzed by pyrosequencing. PCR amplifications were performed to characterize E1 and E2 disruption as an episomal surrogate.
In Brazil, most studies of intra-type variants of human papillomavirus (HPV) have focused on HPV16 and HPV18, but other high-risk HPV types have not been studied. Here, we report the prevalence of lineages and variants of HPV35, HPV45 and HPV58 in cervical cancers from the Amazonian and Southeast Brazilian regions. The most frequent sublineages were A1 for HPV35, B2 for HPV45, and A2 for HPV58.
View Article and Find Full Text PDFCpG methylation at early promoter of HPV16 DNA, in the 3' end of the Long Control Region (3'LCR), has been associated to the presence of episomal forms of viral genome and, consequently, intact E1 and E2 ORFs. The DNA methylation would block the access of E2 viral protein to the E2 binding sites at early-promoter. However, is still unclear if methylation at 3'LCR of HPV16 DNA can also vary depending of other tumor characteristics in addition to viral DNA physical state.
View Article and Find Full Text PDFArticle Synopsis
- - Cervical cancer is a leading cancer in women, mainly linked to HPV types 16 and 18, with a significant part of cases showing genetic diversity that may influence cancer progression.
- - This study analyzed HPV16 and HPV18 genetic variations in 594 Brazilian women with invasive cervical cancer, identifying prevalent lineages before Brazil's public immunization program.
- - Findings revealed that lineage A was most common for both HPV16 (in 217 women) and HPV18 (in 56 women), with HPV16 showing signs of recent variant expansion associated with cancer, unlike HPV18.
Significant effort has been made world-wide to boost biofuels with the expectation of a positive contribution to renewable fuel and greenhouse gas reduction. Jatropha curcas L. has proved to be an opportunistic crop in tropical areas, particularly in unfavorable environments.
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