Effects of crocin on the enhancement of neurogenesis: Involvement of Notch and CREB/BDNF signaling pathways.

Objectives: Adult neurogenesis, the process of generating new neurons, continues throughout life. Unfortunately, this process is insufficient in pathological conditions and needs to be promoted. Crocin, the active component of saffron, affects neurogenesis and .

Exosome odyssey to original line in dental regeneration.

Background: Exosomes are bilayer lipid membrane nanoparticles that can contain DNA, mRNA, proteins, etc. Exosomes can be considered safe because they are produced endogenously. Today, utilizing exosomes as a cell-free procedure is considered to be approved in regenerative medicine.

The Effects of Crocin on Bone and Cartilage Diseases.

Crocin, the main biologically active carotenoid of saffron, generally is derived from the dried trifid stigma of L. Many studies have demonstrated that crocin has several therapeutic effects on biological systems through its anti-oxidant and anti-inflammatory properties. The wide range of crocin activities is believed to be because of its ability to anchor to many proteins, triggering some cellular pathways responsible for cell proliferation and differentiation.

Protective effect of crocin on electromagnetic field-induced testicular damage and heat shock protein A2 expression in male BALB/c mice.

Objectives: Exposure to electromagnetic fields (EMF) emitted from mobile phones may cause a deleterious effect on human health and may affect the male reproductive system. , a carotenoid isolated from , is a phar¬macologically active component of saffron. So, this study was conducted to investigate the protective effect of on the male reproductive system of 60 day old mice after EMF exposure.