Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium.

Study Objectives: Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits.

Integrated support for neuroscience research: from study design to publication.

Computational neuroscience is a new field of research in which neurodegenerative diseases are studied with the aid of new imaging techniques and computation facilities. Researchers with different expertise collaborate in these studies. A study requires scalable computational and storage capacity and information management facilities to succeed.

Provenance for distributed biomedical workflow execution.

Scientific research has become very data and compute intensive because of the progress in data acquisition and measurement devices, which is particularly true in Life Sciences. To cope with this deluge of data, scientists use distributed computing and storage infrastructures. The use of such infrastructures introduces by itself new challenges to the scientists in terms of proper and efficient use.