Publications by authors named "Shayal Pundlik"
ST elevation myocardial infarction (STEMI) is a leading cause of cardiogenic shock (CS) and carries substantial mortality. Cardiac power output (CPO) is the strongest predictor of clinical outcome in CS, and worse outcomes result from concomitant right and left ventricular failure. Right ventricular performance is calculated using right sided CPO.
View Article and Find Full Text PDFBackground: Left bundle area pacing (LBAP) has emerged as an area that appears to be an attractive alternative to other forms of physiological pacing owing to its ease and favorable pacing parameters. Same-day discharge after conventional pacemakers, implantable cardioverter defibrillators, and more recently leadless pacemakers have become routine, especially after the COVID-19 pandemic. With the advent of LBAP, the safety and feasibility of same-day discharge remain unclear.
View Article and Find Full Text PDFArticle Synopsis
- Parkin and PINK1 work together to eliminate damaged mitochondria, with Parkin being controlled by an auto-inhibition mechanism that prevents its activity.
- Phosphorylation by PINK1 and binding of phospho-ubiquitin can activate Parkin, though the timing and specifics of these interactions in cells are not fully understood.
- Experiments show that engineered mutations can reactivate Parkin's function in clearing mitochondria, supporting a model where mitochondrial interactions trigger Parkin activation and subsequent mitophagy processes.