Publications by authors named "Shawn X Y L Foster"
Article Synopsis
- Rett syndrome (RTT) is a rare disorder mainly affecting females, typically linked to mutations in the MECP2 gene, with notable issues in sensory function.
- A study involving skin biopsies from adolescent RTT patients compared to healthy controls showed higher densities of certain nerve fibers associated with sensory functions in RTT patients.
- These findings suggest that the abnormal sensory issues seen in RTT might be related to changes in nerve innervation, prompting the need for deeper exploration of the disorder's neurobiology.
Quantitative sensory testing (QST) is commonly used to evaluate peripheral sensory function in neuropathic conditions. QST measures vary in repeated measurements of normal subjects but it is not known whether QST can reflect small changes in epidermal nerve fiber density (ENFd). This study evaluated QST measures (touch, mechanical pain, heat pain and innocuous cold sensations) for differences between genders and over time using ENFd as an objective-independent measure.
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