Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract.

Objective: To evaluate 3 neurokinin-2 (NK2) receptor antagonists on the basis of their ability to block neurokinin A (NKA)-induced contractile responses in various regions of the guinea pig respiratory tract.

Animals: 48 clinically normal guinea pigs.

Procedure: After euthanasia, the trachea and lungs were removed en bloc.