Evaluation of the Genetic Association Between Adult Obesity and Neuropsychiatric Disease.

Extreme obesity (EO) (BMI >50 kg/m) is frequently associated with neuropsychiatric disease (NPD). As both EO and NPD are heritable central nervous system disorders, we assessed the prevalence of protein-truncating variants (PTVs) and copy number variants (CNVs) in genes/regions previously implicated in NPD in adults with EO ( = 149) referred for weight loss/bariatric surgery. We also assessed the prevalence of CNVs in patients referred to University College London Hospital (UCLH) with EO ( = 218) and obesity (O) (BMI 35-50 kg/m; = 374) and a Swedish cohort of participants from the community with predominantly O ( = 161).

Intranasal glucagon acutely increases energy expenditure without inducing hyperglycaemia in overweight/obese adults.

Aim: To assess the acute effects of 0.7 mg intranasal glucagon (ING) vs intranasal placebo (INP) on food intake and resting energy expenditure (REE).

Methods: A single-blind, crossover study was conducted in 19 overweight/obese adults (15 men, 4 women).

Phenotypic and genetic analysis of an adult cohort with extreme obesity.

Context: Adult extreme obesity (EO) is a growing health concern. The prevalence of known obesity associated co-morbidities namely cardio-metabolic and neuro-psychiatric disease in EO is not fully established. The contribution of pathogenic genetic variants, previously implicated in early childhood onset obesity, to adult EO is also not established.