Challenges in designing and executing clinical trials in a dish studies.

The ever-increasing cost of drug discovery and development represents a significant challenge for the pharmaceutical industry and new strategies to bridge studies between preclinical testing and clinical trials are needed to reduce the knowledge gap prior to first human exposures, and to allow earlier decisions to be made on the further development of drugs. A number of studies have demonstrated that various cell types differentiated from human induced pluripotent stem cells (iPSCs) do not just respond similarly to human tissues in general, but rather recapitulate the drug response of their specific donor's, when exposed to the same drug in vivo. This recapitulation opens the doors to Clinical Trials in a Dish (CTiD), a platform which involves testing, in vitro, medical therapies for safety on cells collected from a sample of human patients, before moving into clinical trials.

Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development.

The pharmaceutical industry is facing unprecedented challenges as the cost of developing new drugs has reached unsustainable levels, fueled in large parts by a high attrition rate in clinical development. Strategies to bridge studies between preclinical testing and clinical trials are needed to reduce the knowledge gap and allow earlier decisions to be made on the continuation or discontinuation of further development of drugs. The discovery and development of human induced pluripotent stem cells (hiPSCs) have opened up new avenues that support the concept of screening for cell-based safety and toxicity at the level of a population.

A representative measure of psychological aggression and its severity.

Surveys of psychological aggression have been plagued by a variety of conceptual and measurement problems. A new measure was devised to more systematically cover a full range of psychologically aggressive actions; to include items for each dimension/category at a milder, moderate, and severe level; to be applicable to dating as well as marital relationships; and to utilize items that were broader in nature to capture all instances of particular types of psychological aggression. Three hundred and eighty-three college students rated the 51 items as to their degree of "psychological abusiveness.