Publications by authors named "Shawheen Shomloo"
Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs.
Antimicrob Agents Chemother
May 2017
Article Synopsis
- Researchers have continued their work by simplifying the structure of a chemosensitizer attached to a known drug, CQ (Chloroquine).
- The simplified version replaces two aromatic rings with a single ring, and this change does not seem to negatively impact the antimalarial effectiveness of the compounds.
- Lab tests indicate that the new single-ring compounds still exhibit activity comparable to CQ, but other mechanisms could also play a role in their effectiveness.
We have previously shown that a "reversed chloroquine (RCQ)" molecule, composed of a chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine resistance in P. falciparum ( Burgess , S. J.
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