Left ventricular diastolic filling in patients with coronary artery disease and normal left ventricular function.

Abnormal left ventricular diastolic filling (DF) has been noted in coronary disease (CD) patients with normal left ventricular function (NLVF). Inclusion of patients with regional wall disease, hypertension, and left ventricular hypertrophy may be responsible for abnormal DF. We evaluated left ventricular DF curves derived from gated blood pool scans in 21 normals (group 1), in 38 CD patients with NLVF specifically defined (group 2), and in 28 CD patients with ejection fractions greater than 50% and regional disease (group 3).

Anastomotic recurrences after low anterior resection. Stapled vs. hand-sewn.

A retrospective study was done comparing the rates of local recurrence in cancer of the rectum treated by low anterior resection using the stapling device or hand-sewn. It was found that there was no increase in recurrences when the stapler was used, even though lower lesions were treated.

Echophonocardiographic estimates of pulmonary artery wedge pressure in mitral stenosis.

The efficacy of noninvasive indexes for predicting pulmonary artery wedge (PAW) pressure was reviewed in 77 patients with mitral stenosis. M-mode echocardiography and phonocardiography were used to measure the aortic valve closure-mitral valve E-point interval (A2-E) and the electrocardiographic Q wave-mitral valve closure interval (Q-C) close to the time of diagnostic cardiac catheterization. During catheterization, in 65 patients PAW pressure was measured and in 12 left atrial (LA) pressure was measured.

Time course alterations of QTC interval due to hypaque 76.

Sequential measurement of QT interval during left ventricular angiography was made 30 seconds and one, three, five and ten minutes after injection of hypaque 76. The subjects were ten patients found to have normal left ventricles and coronary arteries. Significant QTC prolongation occurred in 30 seconds to one minute in association with marked hypotension and elevation of cardiac output.

Changes in epicardial and core temperatures during resuscitation of hemorrhagic shock.

The hypothermic effect of resuscitation solution temperature on epicardial and core temperatures in 15 dogs during hemorrhagic shock was studied. Hemorrhagic shock was induced and dogs were then resuscitated with either body-temperature lactated Ringer's, room-temperature lactated Ringer's, 4 degrees C blood, warmed blood, or cold blood mixed with 50 degrees C lactated Ringer's. There was a significant decrease (p = 0.

The noninvasive assessment of pulmonary capillary wedge pressure in mitral regurgitation.

The interval between the aortic closure sound and the mitral opening snap (A2-OS) has been shown to have a significant inverse correlation with pulmonary capillary wedge pressure (PCW) in mitral stenosis. The present study critically examines the relationship of several noninvasively determined diastolic intervals to PCW in patients with relatively pure mitral regurgitation (MR). Fifty-seven patients with MR of diverse etiologies were studied with echocardiograms and phonocardiograms in addition to right and left heart catheterization.

Intermittent mitral regurgitation due to Beall valve dysfunction: analysis of 13 patients with atrial fibrillation.

A unique hemodynamic event was noted in long-term survivors of mitral valve replacement with the Beall prosthesis. The event was a result of intermittent valve dysfunction and transvalvular mitral regurgitation (MR). At cycle lengths longer than 0.

Isovolumic relaxation period in hypertrophic cardiomyopathy.

Previous reports have demonstrated that patients with hypertrophic cardiomyopathy have a prolonged isovolumic relaxation period as a result of a delay in mitral valve opening, reflecting a reduced rate of fall of left ventricular pressure. This period as measured from the aortic closure sound (A2 on phonocardiogram) to the opening of the mitral valve (on echocardiogram) was determined in 84 patients with hypertrophic cardiomyopathy and compared with findings in 31 normal volunteers. The duration of the isovolumic relaxation period in the 84 patients had a wide range from 0 to 160 ms (mean 71 +/- 32) that was not significantly different from that in normal subjects (63 +/- 11 ms).

The basic mechanisms of fever: considerations for therapy.

In response to threat, particularly the invasion of microorganisms, body temperature rises, a condition called fever. This occurs as phagocytic cells in the body are activated to secrete substances which generate a multitude of host defense responses. Evidence is presented that this response is likely adaptive for the individual and fever acts to synergistically support the responses.

Left atrial transport function.

These studies show that the left atrial booster pump action serves as a supercharger which can increase left ventricular stroke volume in the range of 25 percent; and in patients with aortic stenosis, stroke work in the range of 50 percent (4). These changes can occur in the face of increased resistance to left ventricular filling in clinical conditions such as aortic stenosis where there is diminished left ventricular compliance and in mitral stenosis where there is stenotic resistance to left ventricular filling from the atrium. In spite of this fact, assessment of left atrial function by measurement of cardiac output changes occurring after return from atrial fibrillation to normal sinus rhythm yields erratic and confusing results.

Cardiac tamponade: hemodynamic observations in man.

Hemodynamic studies were performed before and after pericardiocentesis in 19 patients with pericardial effusion. Right atrial pressure decreases significantly, from 16 +/- 4 mm Hg (mean +/- SD) to 7 +/- 5 mm Hg in 14 patients with cardiac tamponade. This change was accompanied by significant increases in cardiac output (3.