Publications by authors named "Shaun Monagle"
Article Synopsis
- The study investigated how the renin-angiotensin system (RAS) affects intestinal inflammation and fibrosis through experiments with human colonic myofibroblasts and analysis of patients with inflammatory bowel disease (IBD).
- Results showed that Angiotensin (Ang) 1-7 decreased cell proliferation and collagen secretion in these myofibroblasts, while Ang II had the opposite effects, emphasizing RAS's role in fibrosis.
- Patients with IBD exhibited higher levels of certain RAS components, and those treated with ACE inhibitors or angiotensin receptor blockers had better outcomes, suggesting that targeting the RAS may help improve IBD management.
Background: The intestinal vitamin D receptor (VDR) remains poorly characterized in patients with inflammatory bowel disease (IBD).
Methods: Colonoscopic biopsies and intestinal resection specimens from the terminal ileum, ascending and sigmoid colon, from patients with and without IBD, were analyzed for VDR mRNA quantification by polymerase chain reaction, and protein localization and semi-quantification by immunohistochemistry. The relationship between VDR and intestinal inflammation, serum 25(OH)D and oral vitamin D intake was elicited.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 has spread rapidly across North America, and CA-MRSA is also increasing in Australia. However, the dominant Australian CA-MRSA strain, ST93-IV [2B] appears distantly related to USA300 despite strikingly similar clinical and epidemiological profiles. Here, we compared the virulence of a recent Australian ST93 isolate (JKD6159) to other MRSA, including USA300, and found that JKD6159 was the most virulent in a mouse skin infection model.
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