Administration safety of medical-grade honey (MGH) in septic synovial structures in horses: 3 cases.

The objective of this study was to investigate the postoperative use of intrasynovial honey as an antimicrobial after treatment for synovial sepsis in horses. One colt and 2 mares were presented with acute lameness, with or without an associated wound. All 3 cases were initially managed with surgical endoscopic or tenoscopic debridement and lavage for treatment of different synovial structures.

Benefits of cyanoacrylate mesh closure following exploratory laparotomy in horses.

Background: Skin closure of laparotomy incisions using topical 2-octyl cyanoacrylate (2-OCA) mesh provides a secure bactericidal barrier in humans, which may reduce the risk of postoperative incisional complications. However, the benefits of using this mesh have not been objectively assessed in horses.

Methods: From 2009 to 2020, three methods of skin closure were used following laparotomy for acute colic, including metallic staples (MS), suture (ST) and cyanoacrylate mesh (DP).

A controlled study evaluating a novel surgical treatment for kissing spines in standing sedated horses.

Objective: To compare the results of a novel minimally invasive surgical technique with intralesional corticosteroid medication, as treatment for overriding dorsal spinous processes (ORDSP) in horses.

Study Design: Retrospective controlled clinical case series.

Animals: Horses (n = 68) with ORDSP.

Repulsion of maxillary and mandibular cheek teeth in standing horses.

Objective: To report the technique and results of cheek teeth repulsion in standing, sedated horses.

Study Design: Case series.

Animals: Horses (n = 12), ponies (6).

Muc5b and Muc5ac are the major oligomeric mucins in equine airway mucus.

Horses frequently suffer from respiratory diseases, which, irrespective of etiology, are often associated with airway mucus accumulation. Studies on human airways have shown that the key structural components of the mucus layer are oligomeric mucins, which can undergo changes of expression and properties in disease. However, there is little information on these gel-forming glycoproteins in horse airways mucus.

Modeling the airway epithelium in allergic asthma: interleukin-13- induced effects in differentiated murine tracheal epithelial cells.

Mucous cells of the airway epithelium play a crucial role in the pathogenesis of human inflammatory airway diseases. Therefore, it is of importance to complement in vivo studies that use murine models of allergic asthma with in vitro mechanistic studies that use murine airway epithelial cells, including mucus-containing cells. In this study, we report the development and characterization of an in vitro culture system for primary murine tracheal epithelial (MTE) cells comprising ciliated cells and a substantial number of mucous cells.

PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum.

We have previously shown that PGE(2) and PGI(2) induce recovery of transepithelial resistance (TER) in ischemia-injured porcine ileal mucosa, associated with initial increases in Cl(-) secretion. We believe that the latter generates an osmotic gradient that stimulates resealing of tight junctions. Because of evidence implicating phosphatidylinositol 3-kinase (PI3K) in regulating tight junction assembly, we postulated that this signaling pathway is involved in PG-induced mucosal recovery.

Effects of hydrocortisone on substrates of energy metabolism in alpacas.

Objective: To evaluate effects of hydrocortisone administration, with and without concurrent administration of insulin, on intermediary metabolism in alpacas.

Animals: 8 adult castrated male alpacas.

Procedure: On each of 2 consecutive days, food was withheld from alpacas for 8 hours.