Synopsis of recent research by authors named "Shaun Hollern"
- Shaun Hollern's research primarily focuses on the genetic and chromosomal abnormalities associated with B-cell precursor acute lymphoblastic leukemia (B-ALL), specifically investigating the role of chromosome 21 anomalies such as intrachromosomal amplification (iAMP21) and copy number neutral loss of heterozygosity (CN-LOH) in the disease.
- In his 2019 study, Hollern identified that CN-LOH of 12q is a recurrent feature in cases of iAMP21-ALL but is absent in other forms of B-ALL, suggesting a unique mechanism linking chromosome 21 alterations to disease progression.
- Another significant aspect of his work involves the creation of xenografts from patient-derived leukemic blasts with iAMP21 to facilitate in vivo studies, enhancing the understanding of clonal dynamics and providing a valuable resource for future functional research and preclinical applications in leukemia.
