A comparison framework for interleaved persistence modules.

We present a generalization of the induced matching theorem of as reported by Bauer and Lesnick (in: Proceedings of the thirtieth annual symposium computational geometry 2014) and use it to prove a generalization of the algebraic stability theorem for -indexed pointwise finite-dimensional persistence modules. Via numerous examples, we show how the generalized algebraic stability theorem enables the computation of rigorous error bounds in the space of persistence diagrams that go beyond the typical formulation in terms of bottleneck (or log bottleneck) distance.

DSGRN: Examining the Dynamics of Families of Logical Models.

We present a computational tool DSGRN for exploring the dynamics of a network by computing summaries of the dynamics of switching models compatible with the network across all parameters. The network can arise directly from a biological problem, or indirectly as the interaction graph of a Boolean model. This tool computes a finite decomposition of parameter space such that for each region, the state transition graph that describes the coarse dynamical behavior of a network is the same.

Identifying robust hysteresis in networks.

We present a new modeling and computational tool that computes rigorous summaries of network dynamics over large sets of parameter values. These summaries, organized in a database, can be searched for observed dynamics, e.g.

Model Rejection and Parameter Reduction via Time Series.

We show how a graph algorithm for finding matching labeled paths in pairs of labeled directed graphs can be used to perform model invalidation for a class of dynamical systems including regulatory network models of relevance to systems biology. In particular, given a partial order of events describing local minima and local maxima of observed quantities from experimental time series data, we produce a labeled directed graph we call the for which every path from root to leaf corresponds to a plausible sequence of events. We then consider the regulatory network model, which can itself be rendered into a labeled directed graph we call the via techniques previously developed in computational dynamics.

Combinatorial representation of parameter space for switching networks.

We describe the theoretical and computational framework for the Dynamic Signatures for Genetic Regulatory Network ( DSGRN) database. The motivation stems from urgent need to understand the global dynamics of biologically relevant signal transduction/gene regulatory networks that have at least 5 to 10 nodes, involve multiple interactions, and decades of parameters. The input to the database computations is a regulatory network, i.

Combinatorial-topological framework for the analysis of global dynamics.

We discuss an algorithmic framework based on efficient graph algorithms and algebraic-topological computational tools. The framework is aimed at automatic computation of a database of global dynamics of a given m-parameter semidynamical system with discrete time on a bounded subset of the n-dimensional phase space. We introduce the mathematical background, which is based upon Conley's topological approach to dynamics, describe the algorithms for the analysis of the dynamics using rectangular grids both in phase space and parameter space, and show two sample applications.