Publications by authors named "Shaun Hang"
Article Synopsis
- Activation of cardiac fibroblasts into myofibroblasts contributes to heart issues like arrhythmias and heart failure, marked by increased expression of α-SMA and collagen secretion.
- TGF-β and mechanical stress trigger this activation, but the potential for reversing this process in human cardiac fibroblasts has not been thoroughly studied.
- The study found that manipulating substrate stiffness and TGF-β receptor inhibition did not restore myofibroblasts to a quiescent state, indicating a loss of responsiveness in chronically activated human cells.
