[Analysis of the causes of cancer negligence and low survival in the patients with malignant neoplasms of ENT and oral cavity in the city of Moscow].

The objective of the present study was to elucidate the causes of late detection of malignant neoplasms of ENT and oral cavity and low survival of the patents with these tumours in Moscow. The secondary objective was to elaborate the organizational measures for reducing the level of negligence and mortality from these malignancies among the city population. It was shown that the main cause behind the negligence is the late application of the patients for the medical assistance.

[TiO2-DNA nanocomposites capable of penetrating into cells].

Methods of noncovalent immobilization of DNA fragments onto titanium dioxide nanoparticles (TiO2) were developed, which led to TiO2-DNA nanocomposites capable of penetrating through cell membranes. TiO2 nanoparticles of different forms (amorphous, anatase, brookit) with enhanced agglomeration stability were synthesized. The particles were characterized by X-ray diffraction, small angle X-ray scattering, infrared spectroscopy and atomic force microscopy.

[Prophylactic medical examination of patients with head and neck tumours in Moscow--continuity of patients' care provided by oncologists and general practitioners].

The primary objective of prophylactic medical examination of oncological patients is reduction of mortality and improvement of the quality of life. Activities of the Department of Head and Neck Tumours of No 1 Oncological Clinical Dispensary are focused on dynamic follow-up of treated patients for early identification of continued tumour growth, diagnosis of relapses and metastases. Compliance with the schedule of control examination in the post-treatment period facilitates early identification of continued tumour growth, diagnosis of relapses and metastases.

[Delayed results of the treatment of patients with laryngeal cancer in Moscow].

The objective of the present study was to analysis results of the follow-up survey involving 1,532 patients with laryngeal cancer residing in Moscow for the period from 1999 till 2005. The five-year survival rates among the patients treated in otolaringological departments of general medical care settings (12.6%) and in specialized oncological centers of Moscow (87.

[Principles of early diagnosis of malignant neoplasms in ENT organs].

According to Moscow city Oncological Dispensary, the number of patients with malignant neoplasms of ENT organs has increased during the last 5 years. In 79-84% of the patients the diseases is diagnosed at stage III-V which leads to rather poor results of treatment. Results of analysis of causes for late diagnosis of ENT neoplasms point out to the necessity to raise oncologic alertness among ambulatory physicians.

[Endoscopic diagnosis of multiple primary cancer of the upper airways].

The authors analyze the results obtained at comprehensive examination of 123 patients with multifocal synchronous and metachronous cancer of the upper respiratory tracts and the lungs. Cancer of the larynx and the lungs was registered in 107 patients, multifocal cancer of the pharynx and lungs in 16 patients. Synchronous and metachronous cancer of the larynx and the lungs was diagnosed in 48 (44.

[Use of new domestic foodstuffs in the treatment of digestive system diseases with food intolerance].

A clinical trial has been performed of the food Unipit-3 and Laktanal based on cow milk proteins subjected to enzymic hydrolysis, dia- and ultrafiltration. A preliminary immunochemical assay of the above products protein component and its testing in anaphylactic shock reaction in animals demonstrated low sensitizing activity of this protein. The results of the trial of the above hypoallergenic foods in patients with food allergy showed their good tolerance and therapeutic efficacy.

[Role of neuropeptides in the pathogenesis of pain syndrome in autonomic and sensory polyneuropathy of occupational etiology and their role in the therapeutic action of laser acupuncture].

Biochemical studies of opiate system in patients with occupational diseases showed the role of the central pain regulating system inducing the pain syndrome in autonomic and sensory polyneuropathy caused by occupational factors. Increased production of the pain-reducing endogenic neuropeptides such as endorphin and leucine enkephalin was found one of the He-Ne laser acting principles which restore the pain adaptation in human. A repeated course of laser therapy would normalize the content of both neuropeptides.

[Cobalt-induced cardiomyopathy in workers engaged in the manufacture of hard alloys].

Four male patients aged 32 to 42 years were followed up. The clinical picture of the disease was typical of dilated (congestive) cardiomyopathy with a subacute onset, development of pronounced heart failure; all the patients were found to have exudate pericarditis. All the men were of the same occupation; they worked at the hard alloy works at a bay of wet grinding in ethanol of metallic Co and hard alloy carbides.

[Functional state and development of diseases of the locomotor system in seamstresses in relation to their work characteristics and degree of physical exertion of the hand muscles].

Physiological and clinical on-the-spot studies were performed of the labour conditions in 3 groups of female sewing-machine operators (respectively, engaged in making women's dresses, men's suits and men's coats). The analysis performed revealed different degrees of physical load and fatigue in the operators depending on the occupational peculiarities. Specific features of the peripheral nervous system and locomotor system disorders were studied in details, along with the causal relationships underlying the degree of physical load and fatiguability, overstrain development and cumulation.

[A biochemical assessment of the glucocorticoid function of the adrenal cortex in patients with occupational bronchial asthma and asthmatic bronchitis].

The article contains a study of the basal level and the circadian rhythm of the hydrocortisone secretion in patients with occupational bronchial asthma and asthmatic bronchitis. Relationships were established between the hydrocortisone secretion levels and severity of the clinical course. Circadian rythm disorders resulted into double hydrocortisone secretion increases at 8 a.

[Biochemical evaluation of metabolic disorders in the tissues of the locomotor system in patients with occupational diseases caused by physical stress].

A group of patients with occupational disease and female sewing-machine operators were medically examined with a broad set of biochemical techniques aimed at the detection of metabolic disorders in the locomotor system tissues. Noninflammatory dystrophic changes were found. The muscular component was dominating in comparison with the osseous one in the genesis of the degenerative dystrophic processes, which manifested in the clinical course.

[Metabolic status in workers engaged in the production of cobalt-containing powder compositions of hard alloys].

A wide-range complex of biochemical techniques was used to study metabolic processes in workers exposed to cobalt and ethanol. In practically healthy workers were found laboratory manifestations of hepato-biliary irritations, hyperpermeability of the hepatocytes' cytoplasmic membrane, cholestasis syndrome, initial manifestations of muscular dystrophy and minor signs of atherosclerosis risks. The biochemical shifts were like those in alcoholism cases.

[An immunochemical analysis of enzymatic hydrolysates of milk and soy proteins intended for the production of specialized nutritional products].

The capacities of immunoelectrophoresis in identification and assay of antigenic protein in enzymatic hydrolysates of milk and soya have been evaluated. The hydrolysates obtained under the action of pancreatin and protosubtilin were studied in milk protein concentrates "Dialact" and casezit and soya protein isolate "Adrex". Two-dimensional immunoelectrophoresis according to Clarke and Freeman was used to analyze the antigenic component spectrum in the samples.

[Prevalence of arterial hypertension, ischemic heart disease and their risk factors in geologists in various regions of the USSR].

The authors presented the results of an epidemiological survey conducted simultaneously for the first time among persons of geological professions in order to reveal the prevalence of arterial hypertension (AH) and coronary heart disease (CHD) with account of labor intensity, climatic and geographic factors. Altogether 1041 men were examined in 4 regions: in Vorkuta (a trans-polar region), Ukhta (a northern region), Chita and the Central region. The highest AH prevalence was detected in Vorkuta (27.