Florid vulval Paget disease exhibiting p16 immunoreactivity and mimicking classic VIN.

The diagnosis of vulval Paget disease is generally relatively straightforward but may be difficult, especially when the Paget cells are few in number. We report 2 cases of the opposite scenario where the Paget cells were present in such large numbers and formed confluent sheets such that they effaced the residual keratinocytes. There were associated epidermal hyperplastic changes in the form of acanthosis, papillomatosis, and hyperkeratosis, and the overall morphology resulted in close mimicry of classic (undifferentiated/human papillomavirus-related) vulval intraepithelial neoplasia.

DOG1 immunoreactivity in uterine leiomyosarcomas.

Aims: DOG1 is a recently described marker of gastrointestinal stromal tumour (GIST) which is considered to be extremely sensitive and, among mesenchymal neoplasms, quite specific for this tumour type. Following the identification of DOG1 immunoreactivity in a uterine leiomyosarcoma, we wished to ascertain how prevalent DOG1 immunoreactivity was in this tumour type.

Methods: We stained a series of uterine leiomyosarcomas (n=26) with DOG1 and with CD117 (c-kit), another marker of GIST.

Enterobius vermicularis causing symptoms of appendicitis in Nepal.

This study set out to determine the prevalence of Enterobius vermicularis in surgically removed appendices and to assess the possible relation of the parasite to acute appendicitis. All 624 surgically removed appendices received in the Department of Pathology, BPKIHS, Dharan, Nepal during 2(1/2) years (August 1999-January 2002) were examined. E.

Diagnostic value of fine needle aspiration cytology in gouty tophi: a report of 7 cases.

Unlabelled: BACKGROUND The diagnosis of gout can be problematic when the presentation is atypical and serum uric acid is borderline elevated. Demonstration of monosodium urate (MSU) crystals in fine needle aspiration (FNA) smears from nodular masses clinically suspected to be tophi establishes the diagnosis unequivocally.

Cases: Of the 7 cases in this study, 4 were suspected clinically to have gouty tophi.

Pyomyoma in a postmenopausal woman: a case report.

Pyomyoma (suppurative leiomyoma of the uterus) is a rare condition associated with a high fatality rate. Only surgical intervention is lifesaving. It usually develops in association with either recent pregnancy or in postmenopausal patients who have underlying vascular disease.

Pigmented trichoblastoma: report of a rare case.

Trichoblastoma is a rare benign skin appendage tumour with follicular differentiation. Pigmented variant of trichoblastoma is an extremely uncommon tumour and only three cases have been described in the literature. We report a rare case of pigmented trichoblastoma in a 54-year-old female.

Paget's disease of the nipple diagnosed on cytology: a case report.

Paget's disease of the breast nipple is an eczematous skin change of the nipple-areola complex often associated with an underlying in-situ or invasive carcinoma. The usefulness of cytology in the diagnosis of Paget's disease has been suggested only in few studies despite the fact that it offers definitive advantages over surgical excision biopsy. Easy practicability, quick, cost-effective and non-invasive stands opposite a limited sensitivity as disadvantage.

Diffuse hyperplastic oncocytosis of parotid gland: a case report.

Oncocytic tumors of salivary glands are rare. Diffuse oncocytosis is the rarest lesion among 3 principal groups of oncocytic lesions as classified by WHO. Only seven cases have been previously reported in the literature.

Clinical presentation of retinoblastoma in Eastern Nepal.

Background: The purpose of the present study was to determine modes of presentation of retinoblastoma and the association between proptosis with orbital extension and histopathologically detectable optic nerve infiltration by the tumour.

Methods: Clinical records and histopathological reports of patients with retinoblastoma were studied retrospectively. The work was undertaken at a tertiary care hospital in eastern Nepal during the period from September 1995 to August 2002.

Fine needle aspiration of lymphadenopathy in visceral leishmaniasis.

Objective: To illustrate the cytomorphologic features of Leishmania lymphadenitis associated with visceral leishmaniasis (V/L) and post-kala-azar dermal leishmaniasis (PKDL) and to highlight the fact that Leishmania lymphadenitis must he included in the differential diagnosis of patients presenting with lymphadenopathy, particularly in areas endemic for the disease.

Study Design: Fine needle aspiration (FNA) was routinely done in 21 cases of lymphadenopathy in VL (18 cases) and PKDL (3 cases), and the detailed cytomorphologic features were correlated with the respective histopathologic findings.

Results: Amastigote forms of Leishman-Donovan (LD) bodies were seen in 19 cases both intracellularly, in histiocytes and multinucleate giant cells, and extracellularly.

Nucleolar organizer regions as a prognostic indicator in epithelial cancers of the ovary.

Recent studies have shown that quantification of silver-stained nucleolar organizer region associated proteins (AgNORs) is correlated with ploidy and proliferative activity in several neoplasms. The prognostic value of this marker, however, has not been well defined in epithelial ovarian carcinomas (EOCs). We studied 84 cases of EOCs in an attempt to assess the potential prognostic significance of AgNORs and to compare the results with other prognostic factors in EOCs.

Germ cell tumors of the ovary: a clinicopathologic study of 121 cases from Nepal.

Background: Although many reports have been published about germ cell tumors of the ovary in developed countries, there has been no such documentation from Nepal. The retrospective study presented here reports the clinicopathologic profile of germ cell tumors of the ovary studied at B. P.

Microcystic papillary adenoma of the nose: a case report.

Microcystic papillary adenoma of nose is rarely seen in nose. This case is reported because of its rarity and to best our knowledge is a first case report from Nepal.

Incidence of pelvic and extrapelvic endometriosis in Eastern region of Nepal.

Endometriosis is described as the presence of endometrial glands or stroma in abnormal locations outside the uterus. It afflicts 10% women of childbearing age. A 5-year retrospective analysis of histopathologically proven cases of endometriosis was done.

Ulcerative post-kala azar mucosal leishmaniasis masquerading as a carcinoma--a case report.

Post kala-azar mucosal leishmaniasis (PKML) is relatively rare in the Indian subcontinent. We describe an ulcerative variant of PKML with nasal involvement in a Nepalese adult male. He had ulcerated plaque over the upper lip with extensive involvement of nasal columella and septum.

Primary squamous cell carcinoma of the endometrium: a case report.

Squamous cell carcinoma of the endometrium is extremely rare female genital malignancy. Only 64 cases have been reported in the literature. A case of primary squamous cell carcinoma of endometrium in a 55-year old-woman is reported.

Primary malignant tumours of eye and adnexa in Eastern Nepal.

Background: The purpose of the present paper was to report the spectrum of primary malignant tumours of eye and adnexa at BP Koirala Institute of Health Sciences, Nepal, from 1995 to 2000.

Methods: A retrospective study of medical records with histopathological confirmation of malignant tumours of the eye and adnexa was done for the years 1995-2000. A total of 116 consecutive medical records from the Department of Pathology at BP Koirala Institute of Health Sciences were retrieved.

Choroidal melanoma with secondary glaucoma.

The case of a 40-year-old female patient with choroidal melanoma with secondary glaucoma presenting as a painful blind right eye is reported. Liver metastasis was detected by ultrasonography. The choroidal tumor measured 2 x 2.

Nasal cerebral heterotopia: a case report.

Nasal cerebral heterotopia (nasal glioma) are rare congenital benign masses of neurogenic origin with intranasal location, or both. An extranasal case is reported in a 2-year-old-boy without any bony defect or connection with brain. Histology and immunohistochemistry confirmed the diagnosis.

Inverted papilloma of nose with orbital involvement and malignant transformation.

We report two cases of inverted papilloma of nose with malignant transformation and orbital involvement in 60 year and 73 year male patients from Nepal. Medial maxillectomy and orbital exenteration were done in both cases. Histo- pathological examination showed areas of squamous cell carcinoma in inverted papilloma in both of the cases.

Inflammatory fibroid polyp of the jejunum presenting as intussusception.

Inflammatory fibroid polyp (IFP) of jejunnum is a rare nonneoplastic lesion of gastrointestinal tract. We report a case of a 45-year-old man presenting with small bowel obstruction due to jejuno-jejunal intussusception of an inflammatory fibroid polyp. To the best of our knowledges, this is the eighth reported case with such a presentation in English medical literature.