Publications by authors named "Shatha Elemian"
Ovarian cancer, although not among the most commonly diagnosed cancers, remains a significant cause of cancer-related mortality in females. Several paraneoplastic syndromes have been associated, and this case study represents a rare manifestation of ovarian cancer, presenting as non-islet cell tumor hypoglycemia (NICTH), characterized by the excessive production of insulin-like growth factor-II (IGF-II) by tumor cells. We report a 55-year-old woman who presented to our hospital with abdominal distension and severe refractory hypoglycemia.
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- This study explored the impact of germline genetic testing (GGT) on cancer care among 3,319 patients in Jordan, identifying how widely it was adopted compared to Western countries.
- A higher frequency of pathogenic germline variants (PGVs) was found in patients who met testing criteria, but a significant portion of PGVs (34.8%) was also identified in those who did not.
- The implementation of universal GGT in Jordan led to important changes in clinical management for a majority of patients, including those who would typically not qualify under standard guidelines.
Article Synopsis
- Recent advancements in multiple myeloma (MM) treatment, including new therapies like immunomodulatory drugs and CAR T-cell therapy, have improved patient outcomes but still face challenges like relapses and treatment resistance.
- Talquetamab, an FDA-approved bispecific antibody targeting GPRC5D, shows promising response rates and a unique side effect profile, making it a significant option for patients with relapsed MM.
- Ongoing clinical trials are exploring talquetamab's effectiveness in combination with other treatments, highlighting the potential for GPRC5D-targeted therapies in MM treatment strategies.
Hepatocellular carcinoma (HCC) is a common worldwide cancer with a poor prognosis despite treatment advancements. Patients typically exhibit signs and symptoms pertaining to the liver. Extrahepatic metastasis of HCC is documented to be as low as 5% of cases.
View Article and Find Full Text PDFBreast cancer susceptibility genes such as , , , and many others are increasingly recognized among our patient population. In addition to their impact on treatment decisions of tested patients themselves, identifying at-risk family members offer opportunities for cancer preventive measures. This is an observational cross-sectional study of adult breast cancer patients with positive breast-cancer-susceptibility germline variants who received treatment at our institution.
View Article and Find Full Text PDFGuideline-Based, Multi-Gene Panel Germline Genetic Testing for at-Risk Patients with Breast Cancer.
Breast Cancer (Dove Med Press)
January 2023
Background: Genetic testing for at-risk patients with breast cancer should be routinely offered. Knowledge generated may influence both treatment decisions and cancer prevention strategies among the patients themselves and their relatives. In this study, we report on the prevalence and patterns of germline mutations, using commercially available next-generation sequencing (NGS)-based multi-gene panels (MGP).
View Article and Find Full Text PDFBackground: Ovarian cancer is one of the most common gynecological malignancies. Due to the absence of effective screening methods, ovarian cancer is usually diagnosed at late stages. Patients with pathogenic and likely-pathogenic germline variants (PGVs) in BRCA1 or BRCA2 harbor elevated risk of developing both ovarian and breast cancers.
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