Publications by authors named "Shatha Al Adawi"
Article Synopsis
- Acquired resistance to cancer treatments, particularly for EGFR mutations, leads to cancer recurrence and limits treatment effectiveness, especially with drugs like osimertinib.
- The study employs molecular dynamics simulations to analyze two specific EGFR mutants (L858R/L718Q and L858R/L792H) that resist osimertinib, compared to the wild-type EGFR.
- Findings indicate that these secondary mutations create additional hydrogen bonds, reducing the binding target exposure for osimertinib and altering the binding affinity, which may inform future drug development strategies.
