School-based randomized controlled trial of an HIV/STD risk-reduction intervention for South African adolescents.

Objective: To test the efficacy of a school-based human immunodeficiency virus/sexually transmitted disease (HIV/STD) risk-reduction intervention for South African adolescents.

Design: A cluster-randomized, controlled design with assessments of self-reported sexual behavior collected before intervention and 3, 6, and 12 months after intervention.

Setting: Primary schools in a large, black township and a neighboring rural settlement in Eastern Cape Province, South Africa.