Publications by authors named "Shashwat S Agarwal"
Blood and lymphatic vessels in the body are central to molecular and cellular transport, tissue repair, and pathophysiology. Several approaches have been employed for engineering microfabricated blood and lymphatic vessels , yet traditionally these approaches require specialized equipment, facilities, and research training beyond the capabilities of many biomedical laboratories. Here we present xurography as an inexpensive, accessible, and versatile rapid prototyping technique for engineering cylindrical and lumenized microvessels.
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- Fibrillar collagens and glycosaminoglycans (GAGs) are crucial components of the extracellular matrix (ECM), and this study investigates how specific GAGs—chondroitin sulfate (CS), dermatan sulfate (DS), and hyaluronic acid (HA)—affect the mechanical and microstructural properties of collagen hydrogels.
- The research reveals that while HA enhances the ECM's stiffness, all GAGs tested do not impact hydraulic permeability, indicating distinct roles in regulating matrix structure and organization.
- The findings emphasize the importance of utilizing various experimental techniques, like mechanical testing and imaging, to better understand the dynamics of collagen self-assembly and how GAGs influence ECM properties at different
Article Synopsis
- Fibrillar collagens and glycosaminoglycans (GAGs) are essential components of the extracellular matrix (ECM), influencing its structure and mechanical properties.
- This study investigates how different GAGs (chondroitin sulfate, dermatan sulfate, and hyaluronic acid) affect ECM properties at a cellular scale, including stiffness, transport efficiency, and microstructure of collagen-based hydrogels.
- The findings reveal that GAGs alter collagen self-assembly kinetics and suggest new methods to study ECM characteristics through techniques like stiffness measurements and turbidity assays.