[Rapid methods for evaluation of hygienic standards of drugs in the air at the workplace].

System of calculating methods for staged prognostication of toxicometric parameters and hygienic standards of synthetic drugs was elaborated. This system gives possibility to substantiate quantitative criteria for determination of capacity and directions of investigations in pharmaceutical industry.

[The testing of the carcinogenicity of dispirotripiperazine derivatives by combined administration with sodium nitrite].

The cancerogenic activity of the dispirotripiperasinium derivatives prospidine and spirobromine was tested in concurrent use with sodium nitrite. The drugs were intragastrically administered once a week. It was combined with sodium nitrite, 35 mg/kg, to non-inbred rats of both sex during 24 months.

[The carcinogenic activity of spirobromine].

The carcinogenic activity of spyrobromin was studied during the chronic experiment on 1.5-2-month-old rats and mice of both sexes. The drug was administered intragastrically and intraperitoneally once a week in the maximally tolerant dose for 24 months.

[The hematotoxic and nephrotoxic actions of dispirotripiperazine derivatives in a chronic experiment].

The effects of dispirotripiperazine derivatives spirobromin and prospidin on the parameters of the peripheral blood and behavioral reactions in a chronic 12-month experiment were studied. The experiment was performed on noninbred rats of both sexes. The maximal tolerated doses of the drugs were administered by two routes (intragastrically or intraperitoneally).

[Methodological approaches to evaluating the sensitizing properties of new drug preparations in preclinical trials].

For testing allergenic activity of 18 drugs with various pharmacological properties the reaction of specific leukocyte agglomeration, specific leukocyte lysis reaction, determination of Mg2+ blood serum content and epicutaneous drug application were used. An attempt was made to establish the relationship between the development of immunological response and the time and duration of allergization, the dosage and routes of allergen administration and also to determine the optimal experimental conditions for appearance of the most pronounced response.

[Evaluation of the effect of the antihistaminic preparations dimebon and diprazin on embryogenesis in rats].

A single administration of dimebon (800 mg/kg) to rats per os (2/3 of the LD50 isoeffective for females) raises the preimplantation death, whereas pipolphen increases the intrauterine lethality and inhibits the development of fetuses. Pipolphen in a dose of 175 mg/kg and dimebon in doses of 300-150 mg/kg (exceeding 25- and 300-150-fold, respectively, the therapeutic dose for man) do not exert any specific embryotropic action.

[Preclinical study of the safety of the antihistaminic preparation dimebon].

The antihistaminic drug dimebon was subjected to toxicological study. It was demonstrated that as regards the level of the mean lethal doses dimebon can be attributed to little toxic substances. Administration of the drug in the doses approximating the therapeutic ones (1 and 5 mg/kg) for 2 months did not produce any alterations in rats, guinea-pigs or dogs.

[Carcinogenic activity of dioxidine].

A study was made of the blastomogenic activity of dioxydin, a new antibacterial broad-action drug. Administration of dioxydin in doses of 20-100 mg/kg (exceeding 2-10-fold the therapeutic dose for humans) to mice and rats intragastrically for 18 months and intraperitoneally (2 years of observation) as well as combined administration of the drug to rats transplacentally and postnatally (1.5 years of observation) did not induce any neoplasms.

[Assessment of the effect of sex steroids on the sexual behavior of the rat at late periods of observation].

A study was made of sexual behavior of male rats exposed to prolonged (4 months) metandrostenolone (MAS) inhalations at the level Limch spec as of the effect of methyltestosterone (MT) on sexual behavior of the progeny following drug applications to the skin of pregnant rats in a dose at the level Limac spec. Methodological approaches to the appraisal of sexual behavior of rats are described. MAS (0.

[Mathematical model of the dose-time-effect relationship in the intramuscular administration of testosterone esters].

Two equations of the dose-time-effect dependence during repeated intramuscular injections of testosterone esters are presented. The equation coefficients characterizing both properties of the drugs injected and individual features of the organs exposed to their action are interpreted. Moreover, two equations for calculating duration of the mitotic cycle of the test organ cells are given.

[Rat postnatal development after bonafton exposure].

The first generation progeny of rats received days 10-13 of pregnancy a new antiviral drug bonaphthon (400 mg/kg) which exerts a toxic effect on females. The progeny did not show postnatal death or reduction of the life span. Moreover, no impairment of muscle work capacity, basal metabolism, cardiovascular system, peripheral blood parameters, or changes in the function of organs and systems were recorded.

[Effect of bonafton on the bodies of pregnant animals].

The toxicity of the original drug bonaphthon was studied in pregnant and nonpregnant mice and rats given the drug orally and intraperitoneally. In a dose of 100 mg/kg bonaphthon had no toxic effect on pregnant rats after 4-time administration per os, while in a single dose of 400 mg/kg the drug elicited side effects such as congestion phenomena and inconsistent dystrophic changes in the parenchymal organs. Toxic effects in the liver were most pronounced when the drug was administered in the earlier periods of pregnancy.

[Effect of bonaphthone on embryogenesis in white rats and mice].

Results of testing the embryotropic activity of bonaphthone used in different doses (700; 400; 100; 50 and 2 mg/kg) are reported. With its oral introduction to pregnant rats bonaphthone, given in doses at the level of the therapeutid one (2 mg/kg) and exceeding it by as much as 25 times (50 mg/kg), was found not to produce any damaging effect on the fetus. With its action in doses of 100 and 400 mg/kg a slight embryotoxic effect was noted.

[So-called infantile cerebral palsy].

On the basis of a comprehensive clinical study of 60 children and a pathomorphological study of the postmortem material the authors established, that in the so-called infantile cerebral paralysis the polymorphic neurological symptomatology is not fully reflected in the existing classifications. Separate clinical forms do not correspond to the pyramidal cerebral pathology, but have an extrapyramidal, cerebellar, hypothalamic and spinal character. The pathomorphological examination detected areas of devastation with a proliferation of the neuroglia, different forms and sizes of cavities in all the brain lobes, in the extrapyramidal system, in the hypothalamic area, cerebellum and spinal cord.

[Quantitative evaluation of the dose-response relationship after intramuscular administration of testosterone and its esters].

Experiments were conducted on rats. A study was made of the reaction of target organs to the intramuscular injection of androgenic preparations--testosterone and its esters (acetate, propionate, phenylpropionate, isocapronate, enantate and caprinate) comparison with anabolic methylandrostendiol. An equation is presented for mathematical description of the dependence of the androgenic effect on the dose of the praparations injected, used in a wide range of doses.

[Study of the allergic properties of medicinal preparations in experiments].

Materials of an experimental study on allergenic properties of prolonged-action sulfanilamides and their semi-products are presented. Investigations involved the use of express-methods with intradermal administration of the substance into the ear and introduction of the agents together with the Freind adjuvant into the hind paw pad of a guinea pig. Experiments ascertained satisfactory dermal-allergic responses to the introduction of allergens differing in their strength by employing the above methods, as express ones for primary evaluation tof allergenic properties of drugs and their semi-products in conducting toxicological investigations.

[Evaluation of the skin resorptive action of testosterone and its esters].

The skin-resorptive action of testosterone and of its ethers (propionate, phenylpropionate, isocapronate, enantate, caprinate) was studied on castrated albino male rats with a one-time application to the skin. The effect was assessed by the growth of the seminal vesicles and the ventral lobe of the prostate. The highest skin-resorptive activity displayed testosterone-propionate and the lowest--testosterone-caprinate.