Publications by authors named "Shashikant Bagade"

Hydrogen peroxide (HO) is suspected to promote cancer. Higher concentrations of HO have always harmed mammalian cells, other living things, as well as the environment. As well, elevated concentrations of HO might cause major health problems such as cancer, cardiovascular disease, asthma, Alzheimer's disease, etc.

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This study investigates the use of pH-responsive nanogels for delivering Bosutinib (BOSU) in colon cancer treatment. Nanogels were formulated using three polymers: hyaluronic acid (HA), carboxymethyl dextran (CMD), and gelatin methacryloyl (GelMA). These nanogels achieved high drug entrapment efficiencies (80-90%) through polymer mixing with BOSU, followed by EDC/NHS cross-linking and sonication.

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Background: Bempedoic acid (BEM) belongs to a category of drugs known as Adenosine triphosphate-citrate Lyase (ACL) inhibitors. It is a prodrug with intracellular activation that is administered orally. Bempedoic acid is used to treat existing atherosclerotic cardiovascular diseases, mainly hypercholesterolemia.

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Article Synopsis
  • Microwaves are being used to extract phytoconstituents from herbal samples more efficiently than traditional methods, which are time-consuming and use excessive solvents.
  • The microwave extraction method is beneficial for preserving heat-sensitive plant components and offers quicker, more selective, and less solvent-intensive extraction.
  • Key factors influencing the extraction efficiency of this technology include solvent properties, exposure time, temperature, and microwave control, highlighting its advantages as a green extraction technique compared to conventional methods.
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Tuberculosis is a highly contagious disease spread by Mycobacterium tuberculosis. It is responsible for highest numbers of death and soon will surpass the deaths caused by HIV. The pandemic disease causes, estimated 10.

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A new, simple, precise, rapid and selective high-performance thin-layer chromatographic (HPTLC) method for the simultaneous quantification of Metronidazole (MTZ) and Miconazole nitrate (MCZ) in gel has been developed. It was performed on silica gel 60 GF254 Thin Layer Chromatographic plates using mobile phase comprising of Toluene: Chloroform: Methanol (3.0:2.

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