Amylin, released from the gastric fundus, stimulates somatostatin and thus inhibits histamine and acid secretion in mice.

Background & Aims: Amylin, a peptide that displays 50% homology with calcitonin gene-related peptide (CGRP), is colocalized with somatostatin in endocrine cells of the gastric fundus. The present study was designed to determine the mechanism of action of amylin on gastric exocrine and endocrine secretion.

Methods: Acid secretion was measured in the isolated mouse stomach by titration.