Publications by authors named "Shashanka Murthy"
Background: Cancer is a leading cause of mortality worldwide. By 2040, over 30 million new cancers are predicted, with the greatest cancer burden in low-income countries. In 2015, the UN passed the Sustainable Development Goal 3.
View Article and Find Full Text PDFQuickly understanding the genomic changes that lead to pathogen emergence is necessary to launch mitigation efforts and reduce harm. In this study, we tracked in real time a 2022 bacterial plant disease outbreak in U.S.
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- - The study aimed to assess the variability in reprogramming efficiency among similar cell lines by accounting for technical differences and comparing the conversion of these lines to two types of cells: neurons and skeletal muscle.
- - Results showed that while reprogramming efficiency was consistent within a specific fibroblast line, there were significant differences between different lines, which could explain discrepancies in existing research.
- - The research indicated that the ability to reprogram cells does not stem from a common subpopulation, as efficiency in converting to one cell type did not predict success in converting to another, suggesting the need for testing multiple cell lines to improve reprogramming outcomes.
Background: Human induced pluripotent stem cells (IPSCs) have enormous potential in the development of cellular models of human disease and represent a potential source of autologous cells and tissues for therapeutic use. A question remains as to the biological age of IPSCs, in particular when isolated from older subjects. Studies of cloned animals indicate that somatic cells reprogrammed to pluripotency variably display telomere elongation, a common indicator of cell "rejuvenation.
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