Selective sub-nucleus ultrasound stimulation induces synaptic potentiation in the mouse hippocampus.

Ultrasound neuromodulation enables to elicit long-lasting effect on neural activities and behavioral responses across species, including humans. However, the potential biophysical mechanism of ultrasound stimulation to induce neuroplasticity still unclear. In this study, we developed a miniature, high target-specificity ultrasound neuro-stimulation chip to selectively stimulate sub-nucleus and investigate the synaptic plasticity induced by ultrasound stimulation in mouse hippocampal slices.

Transcranial focused ultrasound modifies disease progression in SOD1 mouse model of amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS) is a progressively worsening neurodegenerative condition with very few treatment options available. Ultrasound neuromodulation offers promising benefits for treating neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. However, the effects and underlying mechanisms of ultrasound neuromodulation on ALS remain unclear.

The effect of combined ultrasound stimulation and gastrodin on seizures in mice.

Both physiotherapy and medicine play essential roles in the treatment of epilepsy. The purpose of this research was to evaluate the efficacy of the combined therapy with focus ultrasound stimulation (FUS) and gastrodin (GTD) on seizures in a mouse model. Kainic acid-induced seizure mice were divided into five groups randomly: sham, FUS, saline + sham, GTD + sham and GTD + FUS.

Transcranial focused ultrasound stimulation alleviates NLRP3-related neuroinflammation induced by ischemic stroke via regulation of the Nespas/miR-383-3p/SHP2 pathway.

Transcranial focused ultrasound stimulation (tFUS) has emerged as a promising therapeutic strategy for mitigating brain injury in animal models. In this study, the effects and mechanisms of tFUS on ischemic stroke were explored in a transient middle cerebral artery occlusion (MCAO) rat model. Low-intensity tFUS was administered to the ischemic hemisphere 24 h post-MCAO for seven consecutive days.

Tuning Octahedron Sites of CoVO via Cationic Competition for Efficient Oxygen Evolution Reaction.

Doping transition metal oxide spinels with metal ions represents a significant strategy for optimizing the electronic structure of electrocatalysts. Herein, a bimetallic Fe and Ru doping strategy to fine-tune the crystal structure of CoVO spinel for highly enhanced oxygen evolution reaction (OER) is presented performance. The incorporation of Fe and Ru is observed at octahedral sites within the CoVO structure, effectively modulating the electronic configuration of Co.

Transthoracic Ultrasound Improves Cardiac Function in Mice.

Cardiac dysfunction is a severe complication that is associated with an increased risk of mortality in multiple diseases. Cardioprotection solution that has been researched is the electrical stimulation of the vagus nerve to exert cardio protection. This method has been shown to reduce the systemic inflammatory response and maintain the immune homeostasis of the heart.

Functions of metal-phenolic networks and polyphenol derivatives in photo(electro)catalysis.

Phenolic compounds are ubiquitous in nature because of their unique physical and chemical properties and wide applications, which have received extensive research attention. Phenolic compounds represented by tannic acid (TA) play an important role at the nanoscale. TA with a polyphenol hydroxyl structure can chemically react with organic or inorganic materials, among which metal-phenolic networks (MPNs) formed by coordination with metal ions and polyphenol derivatives formed by interactions with organic matter, exhibit specific properties and functions, and play key roles in photo(electro)catalysis.

Recent Advances in the Preparation and Application of Two-Dimensional Nanomaterials.

Two-dimensional nanomaterials (2D NMs), consisting of atoms or a near-atomic thickness with infinite transverse dimensions, possess unique structures, excellent physical properties, and tunable surface chemistry. They exhibit significant potential for development in the fields of sensing, renewable energy, and catalysis. This paper presents a comprehensive overview of the latest research findings on the preparation and application of 2D NMs.

[Regularity of meridian-acupoint reactions of foot three yin meridians in primary dysmenorrhea and secondary dysmenorrhea patients].

Objective: To observe the meridian-acupoint reactions of foot three yin meridians in primary dysmenorrhea(PD) and secondary dysmenorrhea(SD) patients, so as to summarize the rules of meridian-acupoint reaction and acupoints selection.

Methods: Thirty-five patients with PD (PD group), 34 patients with SD (SD group) and 35 healthy subjects (healthy group) were recruited. The compression method was used to examine the lower leg segment of the foot three yin meridians.

A highly sensitive TiO-based molecularly imprinted photoelectrochemical sensor with regulation of imprinted sites by Photo-deposition.

Molecularly imprinted photoelectrochemical sensors (MIPES) have gained significant attention in the detection field due to their high selectivity and accuracy. However, their sensitivity still needs improvement. Here we developed a TiO-based MIPES (TiO NRs/NiOOH/rMIP) to detect ciprofloxacin (CIP).

Highly stable lithium sulfur batteries enhanced by flocculation and solidification of soluble polysulfides in routine ether electrolyte.

Lithium-sulfur batteries (LSBs) are among the most promising next-generation high energy density energy-storage systems. However, practical application has been hindered by fundamental problems, especially shuttling by the higher-order polysulfides (PSs) and slow redox kinetics. Herein, a novel electrolyte-based strategy is proposed by adding an ultrasmall amount of the low-cost and commercially available cationic antistatic agent octadecyl dimethyl hydroxyethyl quaternary ammonium nitrate (SN) into a routine ether electrolyte.

Novel trifunctional electrocatalyst of nickel foam supported CoP/NiMoO heterostructures for overall water splitting and urea oxidation.

The process of electrocatalytic water splitting for hydrogen generation is significantly limited by sluggish kinetics of the anodic oxygen evolution reaction (OER). The efficiency of H electrocatalytic generation can be improved by reducing the anode potential or substituting urea oxidation reaction (UOR) for oxygen evolution process. Here, we report a robust catalyst based on CoP/NiMoO heterojunction arrays supported on nickel foam (NF) for water splitting and urea oxidation.

Al-Incorporated Cobalt-Layered Double Hydroxides for Enhanced Oxygen Evolution through Morphology and Electronic Structure Regulation.

Layered double hydroxides (LDHs) are promising electrocatalytic materials for the oxygen evolution reaction (OER) due to their tunable composition and low cost. Here, we construct ultrathin Al-incorporated Co LDH nanosheets on carbon cloth (CC) by a facile hydrothermal strategy. Compared to Co LDH/CC, the optimized CoAl LDH/CC displays significantly improved OER performance, characterized by low overpotentials of only 171 and 200 mV to reach current densities of 10 mA cm in alkaline and neutral media, respectively, as well as good stability over an extended period.

Structural Engineering of BiVO /CoFe MOF Heterostructures Boosting Charge Transfer for Efficient Photoelectrochemical Water Splitting.

Boosting charge separation and transfer of photoanodes is crucial for providing high viability of photoelectrochemical hydrogen (H ) generation. Here, a structural engineering strategy is designed and synthesized for uniformly coating an ultrathin CoFe bimetal-organic framework (CoFe MOF) layer over a BiVO photoanode for boosted charge separation and transfer. The photocurrent density of the optimized BiVO /CoFe MOF(NA) photoanode reaches a value of 3.

Highly Selective Colorimetric Detection of Cu Using EDTA-Complexed Chlorophyll-Copper/ZnO Nanorods with Cavities Specific to Cu as a Light-Activated Nanozyme.

In this study, chlorophyll-copper (ChlCu)-modified ZnO nanorods (ChlCu/ZnO) were prepared, and then sodium ethylenediamine tetraacetate (EDTA) was used to remove part of Cu in ChlCu, leaving cavities with specific adsorption activity for Cu in E-ChlCu/ZnO. Appropriate EDTA treatment improved the photoactivity of ChlCu/ZnO and the adsorption selectivity to Cu. However, excessive EDTA treatment might lead to the collapse of the ChlCu structure, resulting in a decrease in photoactivity.

Constructing Direct Z-Scheme Heterostructure by Enwrapping ZnIn S on CdS Hollow Cube for Efficient Photocatalytic H Generation.

Rational design hybrid nanostructure photocatalysts with efficient charge separation and transfer, and good solar light harvesting ability have critical significance for achieving high solar-to-chemical conversion efficiency. Here a highly active and stable composite photocatalyst is reported by integrating ultrathin ZnIn S nanosheets on surface of hollow CdS cube to form the cube-in-cube structure. Experimental results combined with density functional theory calculations confirm that the Z-scheme ZnIn S /CdS heterojunction is formed, which highly boosts the charge separation and transfer under the local-electric-field at semiconductor/semiconductor interface, and thus prolongs their lifetimes.

Ultrasound Stimulation of Prefrontal Cortex Improves Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice.

Increasing evidence indicates that inflammatory responses may influence brain neurochemical pathways, inducing depressive-like behaviors. Ultrasound stimulation (US) is a promising non-invasive treatment for neuropsychiatric diseases. We investigated whether US can suppress inflammation and improve depressive-like behaviors.

Non-Cavitation Targeted Microbubble-Mediated Single-Cell Sonoporation.

Sonoporation employs ultrasound accompanied by microbubble (MB) cavitation to induce the reversible disruption of cell membranes and has been exploited as a promising intracellular macromolecular delivery strategy. Due to the damage to cells resulting from strong cavitation, it is difficult to balance efficient delivery and high survival rates. In this paper, a traveling surface acoustic wave (TSAW) device, consisting of a TSAW chip and a polydimethylsiloxane (PDMS) channel, was designed to explore single-cell sonoporation using targeted microbubbles (TMBs) in a non-cavitation regime.

Transcranial Ultrasound Stimulation of the Anterior Cingulate Cortex Reduces Neuropathic Pain in Mice.

Focused ultrasound (FUS) is a potential tool for treating chronic pain by modulating the central nervous system. Herein, we aimed to determine whether transcranial FUS stimulation of the anterior cingulate cortex (ACC) effectively improved chronic pain in the chronic compress injury mice model at different stages of neuropathic pain. The mechanical threshold of pain was recorded in the nociceptive tests.

Enhanced triethylamine-sensing properties of hierarchical molybdenum trioxide nanostructures derived by oxidizing molybdenum disulfide nanosheets.

A 3D α-MoO nanostructure for high-performance triethylamine (TEA) detection was synthesized via the facial oxidation of MoS nanoflowers (NFs) obtained by a hydrothermal process. The influence of the time of hydrothermal process in growing MoS on the morphologies of the final MoO obtained after calcination was investigated. As-obtained MoO and their precursors were systematically characterized by various techniques, such as X-ray diffraction, Raman, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and N adsorption-desorption isotherms.

High temperature induced S vacancies in natural molybdenite for robust electrocatalytic nitrogen reduction.

Defect engineering is an important strategy to regulate electronic structure of electrocatalysts for electrochemical N fixation, aiming at improving the electron state density and enhancing the adsorption and activation of inert N. In this paper, a high-temperature strategy to anneal the natural molybdenite under Ar atmosphere was developed, and the as-obtained molybdenite with S vacancies boosted a high activity for N reduction reaction. In 0.

Neuroprotective Effect of Ultrasound Neuromodulation on Kainic Acid- Induced Epilepsy in Mice.

Preliminary evidence suggests that low-intensity pulsed ultrasound (LIPUS) has neuroprotective effects on ischemic stroke, depression, and other conditions leading to neuronal cell death (e.g., Parkinson's disease).

Microwave-assisted synthesis of hierarchically porous CoO/rGO nanocomposite for low-temperature acetone detection.

Acetone sensors with high response and excellent selectivity are of enormous demand for monitoring the diabetes. This paper has reported a novel porous 3D hierarchical CoO/rGO nanocomposite synthesized by a microwave-assisted method, by which CoO nanoparticles are rapidly and uniformly anchored on rGO nanosheets. The phase composition, surface morphology of the CoO/rGO composites and the effect of rGO on their acetone-sensing performance were systematically investigated.

Microsized Red Luminescent MgAlO:Mn Single-Crystal Phosphor Grown in Molten Salt for White LEDs.

A single-crystalline defect-less phosphor is desired for efficient luminescence of the therein doped optical activators. In this paper, microsized MgAlO:Mn single-crystal phosphors with bright red luminescence were grown in molten LiCl salt at 950 °C, for application in blue LED pumped white lighting. By comparing the phosphor formation from various Mg- and Al-bearing sources, both the template-formation and the dissolution-diffusion processes were evidenced to account for the formation of the microsized MgAlO:Mn crystallites.