Complete response to disitamab vedotin in HER2-low metastatic endometrial carcinoma: a case report and review of the literature.

Endometrial cancer (EC) is one of the most common gynecologic malignancies with increasing morbidity. The prognosis for patients diagnosed with early-stage EC remains favorable; however, for patients with recurrent or metastatic EC, the prognosis is poor and treatment options, until recently, are limited. Antibody drug conjugates (ADCs) represent innovative strategies in cancer treatment; however, there are less investigations regarding their efficacy in EC.

Association between high serum Nogo-B and hypertension in Chinese Han.

Background: Cellular and animal studies have shown that endoplasmic reticulum protein B (Nogo-B) is associated with hypertension, but that association has not been fully studied in humans. Therefore, the expression levels of Nogo-B were investigated in hypertensive patients.

Methods: The plasma Nogo-B levels of 74 patients with hypertension and 67 non-hypertensive patients were measured by enzyme-linked immunosorbent assay.

Molecular characterization of organic aerosol in winter from Beijing using UHPLC-Orbitrap MS.

The urban organic aerosol (OA) may pose a serious threat to human health and ecological environment. In order to understand the molecular characteristics of organic compounds in aerosols, atmospheric PM samples were collected in Beijing and the extracts were analyzed by liquid chromatography-Orbitrap mass spectrometry combined with negative-ion electrospray ionization, positive-ion electrospray ionization, and positive-ion atmospheric pressure photoionization sources. The combination of multiple ionization sources realized the comprehensive molecular characterization of organic compounds in OA, and 1976 (+APPI), 3038 (-ESI), and 4376 (+ESI) molecular formulas were identified in this study.

Long noncoding RNA LINC00657 enhances the malignancy of pancreatic ductal adenocarcinoma by acting as a competing endogenous RNA on microRNA-433 to increase PAK4 expression.

A long noncoding RNAs (lncRNA) called is dysregulated and contributes to tumor progression in a number of human cancer types. However, there is limited information on the expression profile and functions of in pancreatic ductal adenocarcinoma (PDAC). The expression profile of in PDAC was estimated by reverse-transcription quantitative polymerase chain reaction (RT-qPCR).