A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients.

Objective: To compare duration of mechanical ventilation for patients randomized to receive lorazepam by intermittent bolus administration vs. continuous infusions of propofol using protocols that include scheduled daily interruption of sedation.

Design: A randomized open-label trial enrolling patients from October 2001 to March 2004.