Combined EZH2 Inhibition and IKAROS Degradation Leads to Enhanced Antitumor Activity in Diffuse Large B-cell Lymphoma.

Purpose: The efficacy of EZH2 inhibition has been modest in the initial clinical exploration of diffuse large B-cell lymphoma (DLBCL), yet EZH2 inhibitors are well tolerated. Herein, we aimed to uncover genetic and pharmacologic opportunities to enhance the clinical efficacy of EZH2 inhibitors in DLBCL.

Experimental Design: We conducted a genome-wide sensitizing CRISPR/Cas9 screen with tazemetostat, a catalytic inhibitor of EZH2.

Attitudes and Beliefs Toward Computerized Cognitive Training in the General Population.

Introduction: In recent years, computerized cognitive training (CCT) programs have been developed commercially for widespread public consumption. Despite early enthusiasm, whether these programs enhance cognitive abilities in healthy adults is a contentious area of investigation. Given the mixed findings in the literature, researchers are beginning to investigate how beliefs and attitudes toward CCT impact motivation, expectations, and gains after cognitive training.

Prelimbic and infralimbic cortical inactivations attenuate contextually driven discriminative responding for reward.

The infralimbic (IL) and prelimbic (PL) cortices of the medial prefrontal cortex (mPFC) have been shown to differentially control context-dependent behavior, with the PL implicated in the expression of contextually conditioned fear and drug-seeking, and the IL in the suppression of these behaviors. However, the roles of these subregions in contextually driven natural reward-seeking remain relatively underexplored. The present study further examined the functional dichotomy within the mPFC in the contextual control over cued reward-seeking, using a contextual biconditional discrimination (CBD) task.